Funded by the National Natural Science Foundation of China(Nos.20504018,20972014,20604010,20872010 and 20732004);the National Basic Research Program of China(No.2009CB930203)
Chitosan-stavudine (d4T) conjugate with a succinic spacer was synthesized via carbodiimide coupling reaction and structurally characterized. In order to nanosize it for improving its therapeutic properties, the chit...