the National Natural Science Foundation of China (Nos. 81520108030, 21472238,61372194 and 81260672);Professor of Chang Jiang Scholars Program, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (No. 16DZ2280200);the Scientific Foundation of Shanghai China (Nos. 13401900103 and 13401900101);the National Key Research and Development Program of China (No. 2017YFC1700200);the Natural Science Foundation of Chongqing (No. cstc2018jcyjAX0090);Chongqing Education Reform Project of Graduate (No. yjgl52017).
Background: Traditional Chinese medicine (TCM) treats diseases in a holistic manner, while TCM formulae are multi-component, multi-target agents at the molecular level. Thus there are many parallels between the key id...