国家自然科学基金(21210003)

作品数：4被引量：34H指数：3
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Artificial intelligence in drug design被引量：15
《Science China(Life Sciences)》2018年第10期1191-1204,共14页Feisheng Zhong Jing Xing Xutong Li Xiaohong Liu Zunyun Fu Zhaoping Xiong Dong Lu Xiaolong Wu Jihui Zhao Xiaoqin Tan Fei Li Xiaomin Luo Zhaojun Li Kaixian Chen Mingyue Zheng Hualiang Jiang 
supported by the National Natural Science Foundation of China (21210003 and 81230076 to H.J., 81773634 to M.Z. and 81430084 to K.C.);the “Personalized Medicines-Molecular Signature-based Drug Discovery and Development”, Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12050201 to M.Z.);National Key Research & Development Plan (2016YFC1201003 to M.Z.);the National Basic Research Program (2015CB910304 to X.L.)
Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage...
关键词：drug design artificial intelligence deep learning QSAR ADME/T 
New Edges of RNA Adenosine Methylation Modifications
《Genomics, Proteomics & Bioinformatics》2016年第3期172-175,共4页Ye Wang Guifang Jia 
supported by the National Basic Research Program of China (973 Program;Grant No.2014CB964900);the National Natural Science Foundation of China (Grant Nos.21432002,21372022,and 21210003)
Recently an article published in Molecular Cell reveals the mechanism of a nuclear N6-methyladenosine（m^6A）reader,the YTH domain-containing protein 1（YTHDC1）,in regulating pre-m RNA splicing[1].Meanwhile,two addit...
关键词：RNA Adenosine Methylation splicing regulating sequencing adenosine untreated Nature ribosome 
Applying high-performance computing in drug discovery and molecular simulation被引量：3
《National Science Review》2016年第1期49-63,共15页Tingting Liu Dong Lu Hao Zhang Mingyue Zheng Huaiyu Yang Yechun Xu Cheng Luo Weiliang Zhu Kunqian Yu Hualiang Jiang 
supported the National High Technology Research and Development Programme of China(2012AA020301,2012AA01A305);the Chinese Academy of Sciences(KSZD-EWL09-4);the National Natural Science Foundation of China(81230076,21210003)
In recent decades, high-performance computing(HPC) technologies and supercomputers in China have significantly advanced, resulting in remarkable achievements. Computational drug discovery and design,which is based on ...
关键词：HIGH-PERFORMANCE computing computational DRUG DISCOVERY and design virtual SCREENING molecular dynamics simulation protein FOLDING 
Methylation Modifications in Eukaryotic Messenger RNA被引量：16
《Journal of Genetics and Genomics》2014年第1期21-33,共13页Jun Liu Guifang Jia 
supported by the grant from the National Natural Science Foundation of China (No. 21210003)
RNA methylation modifications have been found for decades of years, which occur at different RNA types of numerous species, and their distribution is species-specific. However, people rarely know their biological func...
关键词：RNA methylation N7-methylguanosine （m7G） N6-methyladenosine （m6A） 5-methylcytosine （mSC） 
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