Project supported by the National Natural Science Foundation of China (Nos. 20025207. 20272071, 20372075 and 20321202) and the Chinese Academy of Sciences (No. KGCX2-SW-209). Dedicated to Professor Xikui Jiang on the occasion of his 80th birthday.
Synthesis of five simple analogues of peroxyplakoric acid by using Kobayashi's method to construct the key 1,2-dioxane core is detailed.