Project suported by the National Natural Science Foundation of China (Nos. 20372028, 20472026, 20525206, 20021001) and the Specialized Research Fund for the Doctoral Program in Higher Education Institutions of the Ministry of Education of China.
A readily available β-sulfonamide alcohol-titanium complex was found to be effective on promoting the asymmetric addition reaction of an alkynylzinc reagent to unactivated simple ketones under very mild conditions. A...