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国家自然科学基金(30721063): 作品数：17被引量：21H指数：2; 导出分析报告; 相关作者：张业沈珝琲米洋常永生方福德更多>>; 相关机构：中国医学科学院北京协和医学院中国医学科学院基础医学研究所山西医科大学第一医院阳泉煤业（集团）有限责任公司更多>>; 相关期刊：《Science Bulletin》《中国医学科学院学报》《科学通报》《Chinese Medical Sciences Journal》更多>>; 相关主题：REGULATIONNEURONAL_DIFFERENTIATIONEZH2组蛋白H3REPRESSION更多>>; 相关领域：生物学医药卫生农业科学航空宇航科学技术更多>>

Lysine-specific Demethylase 1 Represses THP-1 Monocyte-to-macrophage Differentiation: 《Chinese Medical Sciences Journal》2013年第2期82-87,共6页Rui-feng Yang Guo-wei Zhao Shu-ting Liang Hou-zao Chen De-pei Liu; Supported by National Natural Science Foundation of China(31271227,30721063,81161120551);National Basic Research Program of China(973 Program,2011CB503902,2011CB965203); Objective To investigate the role of lysine-specific demethylase 1 （LSD1） in the process of THP-1 monocyte-to-macrophage differentiation. Methods Quantitative reverse transcription-polymerase chain reaction （qRT-...; 关键词：lysine-specific demethylase 1 INTERLEUKIN-6 H3K4 methylation monocyte-to-macrophage differentiation

Regulation of erythroid differentiation by miR-376a and its targets被引量：6: 《Cell Research》2011年第8期1196-1209,共14页Fang Wang Jia Yu Gui-Hua Yang Xiao-Shuang Wang Jun-Wu Zhang; The authors thank Drs Hua Bai and Cuimin Lu from the Millitary General Hospital of Beijing for assistance in umbilical cord blood collection. This work was supported by grants from the National Natural Science Foundation of China （30871249 and 30721063）; the Specific Fund of National Laboratory of China （3060204）; and IBMS, CAMS （2009RC03）.; Lineage differentiation is a continuous process during which fated progenitor cells execute specific programs to produce mature counterparts. This lineage-restricted pathway can be controlled by particular regulators,...; 关键词：microRNA-376a cyclin-dependent kinase 2 （CDK2） Argonaute 2 （Ago2） erythroid differentiation

Inhibition of SIRT1 Increases EZH2 Protein Level and Enhances the Repression of EZH2 on Target Gene Expression: 《Chinese Medical Sciences Journal》2011年第2期77-84,共8页Chih-chuan Liang; Supported by National Natural Science Foundation of China (30721063);National Basic Research Program of China (973 Program) (2005CB522402, 2006CB910403);National Laboratory of Medical Molecular Biology grant (2060204);Beijing municipal government grant (YB20081002301); Objective To study the regulatory roles of SIRT1 on EZH2 expression and the further ef-fects on EZH2's repression of target gene expression. Methods The stable SIRT1 RNAi and Control RNAi HeLa cells were established b...; 关键词：SIRT1 EZH2 Polycomb repression complex trimethylated H3K27

NF-E2:a Novel Regulator of Alpha-hemoglobin Stabilizing Protein Gene Expression被引量：2: 《Chinese Medical Sciences Journal》2010年第4期193-198,共6页Guo-wei Zhao Rui-feng Yang Xiang Lu Mitchell J. Weiss De-pei Liu Chih-chuan Liang; Supported by National Natural Science Foundation of China (30130026, U0632005, 30721063);National Basic Research Program of China (973 Program) (2011CB964803);National Laboratory of Medical Molecular Biology grant (2060204);Beijing municipal government grant (YB20081002301); Objective To investigate whether α-hemoglobin stabilizing protein (AHSP), the α-globin-specific molecular chaperone, is regulated by erythroid transcription factor NF-E2. Methods We established the stable cell line ...; 关键词：α-hemoglobin stabilizing protein NF-E2 ERYTHROPOIESIS GATA-1 H3K4 trimethylation

Epigenetic Repression of SATB1 by Polycomb Group Protein EZH2 in Epithelial Cells被引量：1: 《Chinese Medical Sciences Journal》2010年第4期199-205,共7页Chih-chuan Liang; Supported by National Natural Science Foundation of China (30721063);National Basic Research Program of China (973 Program) (2005CB522402, 2006CB910403);National Laboratory of Medical Molecular Biology grant (2060204);Beijing municipal government grant (YB20081002301); Objective To study the regulatory mechanism of SATB1 repression in cells other than T cells or erythroid cells, which have high expression level of SATB1. Methods HeLa epithelial cells were treated with either histone...; 关键词：SATB 1 EZH2 Polycomb group protein gene silencing trimethylated H3K27

Regulation of Acyl-coenzyme A:Cholesterol Acyltransferase 2 Expression by Saturated Fatty Acids被引量：4: 《Chinese Medical Sciences Journal》2010年第4期222-227,共6页Zhu-qin Zhang Hou-zao Chen Rui-feng Yang Ran Zhang Yu-yan Jia Yang Xi De-pei Liu Chih-chuan Liang; Supported by National Natural Science Foundation of China (30721063);National High Technology Research and Development Program of China (863 Program) (2006AA02A406);National Basic Research Program of China (973 Program) (2006CB503801);Special Fund of the National Laboratory of China (2060204); Objective To verify the regulation of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT 2), which is associated with cholesterol metabolism, by saturated fatty acids (SFAs). Methods Palmitic acid (PA), the most abun...; 关键词：acyl-coenzyme A：cholesterol acyltransferase 2 gene expression saturatedfatty acid

Role of Acetylated p53 in Regulating the Expression of map2 in Retinoic Acid-induced P19 Cells被引量：1: 《Chinese Medical Sciences Journal》2010年第2期71-75,共5页Li Zhang Li Yan Ye Zhang Ning-hua Wu Yu-fei Shen; Supported by National Natural Science Foundation of China (30871382,30721063);National Basic Research Program of China (973 Program) (2005CB522405);Special Funds of State Key Laboratories (2060204); Objective To investigate the regulatory mechanisms of acetylated p53 in the expression of microtubule-associated protein-2(MAP2) in neuronal differentiation of P19 cells induced by all-trans retinoic acid(RA).Methods ...; 关键词：P53 p300/CBP associated factor microtubule-associated protein-2 retinoic acid neuronal differentiation

D-Tyr-tRNA^(Tyr) Deacylase,a New Role in Alzheimer's-associated Disease in SAMP8 Mice被引量：2: 《Chinese Medical Sciences Journal》2010年第2期90-94,共5页wei Liu Chang Liu Jing-xi Zhu Ai-hua Li Zhi-qiang Zhao Bin Yin Xiao-zhong Peng; Supported by National Natural Science Foundation of China (30721063); Objective To assess the expression level of D-Tyr-tRNATyr deacylase(DTD) in SAMP8 mice and speculate the function of DTD in disorders associated with Alzheimer's disease(AD).Methods Altogether 12 SAMP8 mice and 12 SAM...; 关键词：D-Tyr-tRNA^Tyr deacylase D-amino acid SAMP8 mice neurodegenerative disease

PGC-1β调节大鼠ALAS-1基因表达机制的初步探讨: 《基础医学与临床》2010年第6期587-592,共6页刘阳邵迪方福德常永生; 国家重点基础研究发展计划(973计划)(2004CB518602和2006CB503909);国家高技术研究发展计划(863计划)(2006AA02Z192);国家自然科学基金(30700386和30721063); 目的检测PGC-1β在人肝癌细胞(Hep G2)和大鼠肝原代细胞中调节大鼠ALAS-1基因表达。方法在Hep G2细胞中瞬时转染PGC-1β,用双荧光报告系统检测过表达PGC-1β时大鼠ALAS-1启动子报告基因的活性变化。同时构建了5′端顺式元件系列截短和...; 关键词：PGC-1β NRF-1 ALAS-1 转录调控

PGC-1α协同ERRα在人肝癌细胞中调节小鼠SHP转录: 《基础医学与临床》2010年第6期593-597,共5页朱镠娈崔颖方福德常永生; 国家重点基础研究发展计划(973计划)(2004CB518602和2006CB503909);国家高技术研究发展计划(863计划)(2006AA02Z192);国家自然科学基金(30700386和30721063); 目的检测PGC-1α和ERRα在人肝癌细胞(HepG2)中对小鼠SHP转录的影响,鉴定ERRα调节SHP启动子利用的顺式元件。方法在HepG2细胞和人胚肾细胞(293A)中瞬时转染ERRα和/或PGC-1α,双荧光酶报告基因实验检测小鼠SHP启动子的活性。构建5′删...; 关键词：PGC-1Α ERRα SHP 转录调控

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