Acknowledgements We thank Dr Minyuan Peng of Xiangya Hospital for flow cytometry analysis. Funding This work was supported by a grant from the National Natural Science Foundation of China (30570783).
Polycomb repressive complex 2 (PRC2), which mediates trimethylation of lysine 27 on histone H3 (K27me3), plays an important role in many types of stem cell differentiation. Here, we try to reveal how PRC2, PRC2-me...