supported by the National Natural Science Foundation of China (32471049,32170984,32471188,32200802);Natural Science Foundation of Shandong Province (ZR2023QH110)。
Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease(PD),supporting the“body-first”hypothesis.However,there remains a notable absence of PD-specific ani...
supported by the National Natural Science Foundation of China (42276103)。
Feeding behavior is regulated by a complex network of endogenous neuropeptides.In chordates,this role is suggested to be under the control of diverse factors including thyrotropin-releasing hormone(TRH).However,whethe...
supported by the Postdoctoral Fellowship Program of CPSF (GZC20231064);China Postdoctoral Science Foundation (2024M761345);Guangzhou Basic and Applied Basic Research Foundation (2024A04J6615);Scientific Research Project of Southern Medical University Stomatological Hospital (PY2023004);National Key Research and Development Program of China (2021YFA0805300);National Natural Science Foundation of China (82171244,32470564)。
Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death.Animal models play a pivotal role in elucidating biological processe...
supported by the Foundation of Gansu Key Laboratory of Protection and Utilization for Biological Resources and Ecological Restoration in Longdong (LDSWZY202103);Natural Science Foundation of Gansu Province (22JR5RM210)to B.P.L.;Gansu Ziwuling Ecosystem Observation and Research Station (20JR10RA658)。
Avian genomes exhibit compact organization and remarkable chromosomal stability.However,the extent and mechanisms by which structural variation in avian genomes differ from those in other vertebrate lineages are poorl...
supported by the National Natural Science Foundation of China (32070979);Shenzhen Science and Technology Program (JCYJ20220530161604009,JCYJ20240813150734043);Key Research and Development Program of Shaanxi (2024SF,YBXM,050);Fundamental Research Funds for the Central Universities (31020190QD004,3102019YX01001);Double First-Class Project of China Pharmaceutical University (CPUQNJC22_02);Global Pharmaceutical Development Alliance Plan of China Pharmaceutical University (1302090024-05)。
DNA2,a multifunctional enzyme with structure-specific nuclease,5'-to-3'helicase,and DNA-dependent ATPase activities,plays a pivotal role in the cellular response to DNA damage.However,its involvement in cerebral ische...
supported by the National Natural Science Foundation of China (U2002218,81874274);Yunnan Health Training Project of High Level Talents (L-2017027);Project of Cross-border Control and Quarantine Innovation Group of Zoonosis of Dali University (ZKPY2019302)to Y.Z.Z;Open Project of Yunnan Key Laboratory of Biodiversity Information (BIKF22-02);Youth Innovation Promotion Association of the Chinese Academy of Sciences;Yunnan Revitalization Talent Support Program Young Talent Project to X.L.Y。
The family Hepeviridae has seen an explosive expansion in its host range in recent years,yet the evolutionary trajectory of this zoonotic pathogen remains largely unknown.The emergence of rat hepatitis E virus(HEV)has...
supported by the National Natural Science Foundation of China (32060755);Natural Science Foundation of Inner Mongolia (2024MS03001);Inner Mongolia Autonomous Region Open Competition Projects (2022JBGS0018);Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region (NJYT23090);Inner Mongolia Autonomous Region Science and Technology Leading Team (2022LJRC0006);Inner Mongolia Autonomous Region Science and Technology Major Project (2021ZD0009);Major Agricultural Science and Technology Project of the Ministry of Agriculture and Rural Affairs (NK2022130203);Central Government Guides Local Science and Technology Development Funds (2022ZY0212);Inner Mongolia Autonomous Region High-level Talent Support Program;Inner Mongolia University Chief Scientist Program。
Somatic cell nuclear transfer(SCNT)has been successfully employed across various mammalian species,yet cloned animals consistently exhibit low pregnancy rates,primarily due to placental abnormalities such as hyperplas...
supported by the National Natural Science Foundation of China (31861143023,31872252);Strategic Priority Research Program of the Chinese Academy of Sciences (XDA20050201)。
Animal adaptation to environmental challenges is a complex process involving intricate interactions between the host genotype and gut microbiome composition.The gut microbiome,highly responsive to external environment...
supported by the National Natural Science Foundation of China (32373181);National Key Research and Development Program (2023YFD2400700);Science and Technology Plan Project of Fujian Province (2022L3059);High-quality Development of Marine and Fishery Industry Special Fund Project of Fujian Province (FJHYF-L-2023-5);Open Fund of Fujian Province Key Laboratory of Special Aquatic Formula Feed (TMKJZ2302)。
Small RNAs(sRNAs)are a class of molecules capable of perceiving environmental changes and exerting posttranscriptional regulation over target gene expression,thereby influencing bacterial virulence and host immune res...