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Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice: 《Acta Pharmacologica Sinica》2024年第10期2061-2076,共16页Jian Lu Xue-jian Zhao Yuan Ruan Xiao-jing Liu Xuan Di Rui Xu Jia-ying Wang Min-yi Qian Hong-ming Jin Wen-jun Li Xu Shen; supported by the National Natural Science Foundation of China(82273930);Innovative Research Team of Six Talent Peaks Project in Jiangsu Province(TD-SWYY-013);the National Natural Science Foundation for Young Scientists of China(82304468);the Natural Science Foundation for Young Scientists of Nanjing University of Chinese Medicine(XPT82304468);the National Natural Science Foundation for Young Scientists of China(82204486);the Natural Science Foundation for Young Scientists of Nanjing University of Chinese Medicine(XPT82204486);the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(No.2020YLXK018)and“Qing Lan”project.; Paclitaxel(PTX)serves as a primary chemotherapy agent against diverse solid tumors including breast cancer,lung cancer,head and neck cancer and ovarian cancer,having severe adverse effects including PTX-induced periph...; 关键词：paclitaxel-induced peripheral neuropathy paclitaxel-induced hypersensitivity reactions DESLORATADINE 5HTR2A NLRP3 astrocytic neuroinflammation

Effect and safety of different doses of desloratadine citrate disodium in patients with chronic spontaneous urticaria in Chinese Han population: 《Chinese Medical Journal》2024年第20期2483-2485,共3页Ke Xue Mengmeng Li Lei Wang Yi Sun Tongxiang Zeng Bing Liu Yong Cui; Chronic spontaneous urticaria(CSU)is defined as the spontaneous appearance of wheals,angioedema,or both for more than six weeks due to known or unknown causes.The prevalence of CSU was found to be higher in Asian stud...; 关键词：doses PATIENTS DISODIUM

Desloratadine alleviates ALS-like pathology in hSOD1^(G93A)mice via targeting 5HTR2A on activated spinal astrocytes: 《Acta Pharmacologica Sinica》2024年第5期926-944,共19页Jian Lu An-xu He Zhuo-ying Jin Meng Zhang Zhong-xin Li Fan Zhou Lin Ma Hong-ming Jin Jia-ying Wang Xu Shen; supported by the National Natural Science Foundation of China(82273930);the National Natural Science Foundation for Young Scientists of China(82304468,82304494,82204486);Major Program of the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(23KJA350002);the Natural Science Foundation for Young Scientists of Nanjing University of Chinese Medicine(XPT82204486);Natural Science Foundation of Jiangsu Province(BK20200570).; Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease with progressive loss of motor neurons in the spinal cord,cerebral cortex and brain stem.ALS is characterized by gradual muscle atrophy and dyskin...; 关键词：amyotrophic lateral sclerosis serotonin receptor 2A DESLORATADINE hSOD1^(G93A)mice spinal astrocytes NLRP3 inflammasome activation

Effects of Desloratadine Citrate Disodium combined with Budesonide suspension on serum IgE, EOS and inflammatory factors in patients with CRS after endoscopic sinus surgery: 《Journal of Hainan Medical University》2017年第15期57-60,共4页Meng Bi Cong Wang Fei Yang; Objective: To observe the clinical application of Desloratadine Citrate Disodium combined with Budesonide suspension in patients with chronic rhinosinusitis CRS after endoscopic sinus surgery, and analyze the change o...; 关键词：DESLORATADINE CITRATE DISODIUM BUDESONIDE nasal spray Endoscopic SINUS surgery Chronic RHINOSINUSITIS

Method Development and Validation for Simultaneous Estimation of Montelukast Sodium and Desloratadine by RP-HPLC: 《American Journal of Analytical Chemistry》2015年第8期651-658,共8页Bonthu Mohan Gandhi Atmakuri Lakshmana Rao Jangala Venkateswara Rao; A novel, precise, accurate, rapid and cost effective isocratic reverse-phase high performance liquid chromatographic (RP-HPLC) method was developed, optimized and validated for the simultaneous estimation of Monteluka...; 关键词：MONTELUKAST SODIUM DESLORATADINE HPLC VALIDATION

Synthesis and biological evaluation of novel derivatives of desloratadine被引量：2: 《Chinese Chemical Letters》2013年第6期531-534,共4页Shuai Mu Xiao-Shuai Xie Duan Niu Da-Shuai Zhang Deng-Ke Liu Chang-Xiao Liu; project was supported by National 973 Plan(Nos. 2010CB735602 and 2012CB724002);National Major Scientific and Technological Special Project for "Significant New Drugs Development"(No.2011ZX09401-009); Series of novel derivatives of desloratadine designed as arginine vasopressin receptor antagonists were synthesized and structurally characterized by melting points,^1H NMR and HRMS.Their in vivo diuretic activities w...; 关键词：Derivatives of desloratadine Arginine vasopressin receptor antagonists Diuretic activity

Quantification of desloratadine in human plasma by LC-ESI-MS/MS and application to a pharmacokinetic study被引量：5: 《Journal of Pharmaceutical Analysis》2012年第3期180-187,共8页Venkata Suresh Ponnuru B.R. Challa Ramarao Nadendla; support received(for providing literature survey)from IICT(Indian Institute of Chemical Technology),Hyderabad,India;the APL Research Center Pvt Ltd, Hyderabad, India; A simple, sensitive, and specific liquid chromatography tandem mass spectrometry (LC-MS/ MS) method was developed for the quantification of desloratadine (DL) in human plasma using desloratadine-d5 (DLD5) as an intern...; 关键词：Mass spectrometry DESLORATADINE BIOEQUIVALENCE Pharmacokinetic study

在8000英尺模拟座舱高度6小时内Desloratadine对于飞行没有影响: 《民航医学》2004年第4期36-36,共1页孙晓艳; 在飞行中飞行员和机组成员必须保持持续性警觉。因此，大范围地禁止使用具有镇静作用的抗组胺药物。Desloratadine是一种长效、无镇静作用的抗组胺药物。本研究的目的是测定其对于飞行的影响，选择健康的志愿者在模拟座舱压力的条件下...; 关键词：抗组胺药物镇静作用双盲影响健康飞行员用具座舱成员

地雷他定—Desloratadine（Neoclarityn）: 《国外新药介绍》2002年第3期11-11,共1页朱晓红; 关键词：地雷他定 DESLORATADINE 非镇静抗组胺剂季节过敏性鼻炎

过敏性鼻炎治疗药地洛他定(desloratadine): 《国外医药（合成药．生化药．制剂分册）》2002年第2期119-119,共1页李晓东; 关键词：地洛他定组胺H1受体拮抗剂过敏性鼻炎临床观察药理学

DESLORATADINE