BACKGROUND Diethylnitrosamine(DEN)induces hepatic neoplastic lesions over a prolonged period.AIM To investigate the promotive action of 2-acetylaminofluorene(2-AAF)when combined with DEN in order to develop a rat mode...
Supported by NIH(Du CY),No.R21CA241025-01;NIH(Du CY),No.RO1CA158323;NCI RO1 Diversity Supplement(Du CY),No.R01CA158323-05S;National Center for Advancing Translational Sciences of the National Institutes of Health(Du CY),No.2UL1TR001425-05A1;University of Cincinnati Center for Environmental Genetics-NIH/NIEHS Award(Du CY),No.P30 ES006096;Pathways to Cancer Therapeutics T32(Du CY and Vilfranc CL),No.CA117846-12.
BACKGROUND BIR repeat-containing ubiquitin conjugating enzyme(BRUCE)is a liver tumor suppressor,which is downregulated in a large number of patients with liver diseases.BRUCE facilitates DNA damage repair to protect t...