This work is supported by the US National Institutes of Health(NIH)R01ES025909,R01DK104656,R01DK080440,R21AA022482,R21AA024935;VA Merit Award 1I01BX002634,P30 DK34989(Yale Liver Center);the National Natural Scientific Foundation of China(Grant No.81572443)(to L.Wang).
Background and Aim:Pyruvate dehydrogenase kinase 4(PDK4)is a metabolism switch that regulates glucose oxidation and the tricarboxylic acid cycle(TCA cycle)in the mitochondria.Liver detoxifies xenobiotics and is const...