supported by the Korea Institute of Toxicology(KIT)Research Program[No.2710008763(KK-2401-01)];the Korea Environmental Industry&Technology Institute(KEITI)through the Core Technology Development Project for Environmental Diseases Prevention and Management[No.2480000072(RS-2021-KE001705)]。
Background:Picropodophllotoxin(PPT),a principal component of Podophyllum hexandrum root,demonstrates various beneficial biological activities in multiple cancer types,including antitumor and antiproliferative properti...
D-allulose, also known by the name D-psicose or just allulose, is a rare keto-sugar epimer of D-fructose in the third carbon (C3), and naturally occurs in small quantity in fruits such as grapes and figs. It is low ca...
supported by the National Natural Science Foundation of China(Grant Nos.81430087 and 81673396)
Because many therapeutic agents are contaminated by epimeric impurities or form epimers as a result of metabolism, analytical tools capable of determining epimers are increasingly in demand. This article is a proof-of...
National Natural Science Foundation of China(NSFC,Grant No.21072017)
Using the potent anticancer agent 2-deoxy-2-chloro-1-amino sugar as a lead compound, its analogs were prepared in 6 steps starting from D-glucal. The key step was the synthesis of 2-chloro-1-acetamido sugars using (C...
A detailed analysis of benzofuranone compounds under multiple tandem mass spectrometry (ESI-MS^n) conditions is reported. Element composition data of the fragment ions were obtained with the aid of comparison of the...
Podophyllotoxin,picropodophyllotoxin and their eight esters were studied using EI MS.The 2-epimers of podophyllotoxin and its esters can be identified by calculating the rate of relative abundance of m/z 168,396 to mo...
This work was supported by the NNSFC(No.20372029 and No.20021001-QT Program);by the Key Project of Chinese Ministry of Education(No.104178).
A pair of epimers of highly-oxygenated monoterpenes were isolated from the traditional Chinese medicine Eupatorium fortunei. Their structures were elucidated on the basis of the spectral analysis as (1R*, 2S*, 3R*...
The tricyclic compound 1, a key intermediate of the pentacyclic core of Et 743 and its analogues, was synthesized. Its 11-epimer was found as the product of racemization when BOP was used as the coupling agent, but no...
Project supported by the National Natural Science Foundation of China
(+)-Preussin (1) and its 5-epimer were synthesized from the divinylcarbinol (3) with Sharpless asymmetric epoxidation of 3 and the oxidative cyclization of 9 with PDC as the key steps.