CHIP-ON-CHIP

作品数:3被引量:13H指数:2
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相关作者:孙清华韩蓓蓓王凤丽石建涛徐学文更多>>
相关机构:山东大学上海交通大学医学院附属瑞金医院上海大学教育部更多>>
相关期刊:《计算机应用与软件》《Cell Research》《Journal of Genetics and Genomics》更多>>
相关基金:国家自然科学基金国家高技术研究发展计划国家重点基础研究发展计划更多>>
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基于非独占式并行计算技术的ChIP-on-chip芯片分析平台
《计算机应用与软件》2009年第8期10-13,共4页杨旭智 石建涛 韩蓓蓓 王萍 王健 张济 王侃侃 
国家自然科学基金项目(30670436);国家高科技研究发展项目(2006AA02Z302)
随着"后基因组时代"的到来以及各种高通量组学技术的发展,ChIP-on-chip这一新兴的研究细胞内蛋白质与全基因组DNA之间调控机制的实验技术已逐渐成熟并推广。然而由此产生的海量数据也给生物学意义的整合与数据挖掘带来了严峻的挑战。针...
关键词:CHIP-ON-CHIP 并行计算 系统监控 
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells被引量:6
《Cell Research》2008年第12期1177-1189,共13页Xiaosong Liu Jinyan Huang Taotao Chen Ying Wang Shunmei Xin Jian Li Gang Pei Jiuhong Kang 
We thank Drs J Zhao, DS Li, L Xiao (Chinese Academy of Sciences, China), Drs B Leo and H Wang (Agilent Technologies, USA) for helpful discussions and technical assistance, and Drs HK Mei and Y Qiu (GlaxoSmithKline, UK) for the DAVID analysis. This research was supported by the Ministry of Science and Technology (2005CB522406, 2006CB943900, 2007CB947904, 2007CB947100, 2009CB941100, and 2007CB948000), National Natural Science Foundation of China (30621091, 30625014, 30623003, and 90713047), Shanghai Municipal Commission for Science and Technology (07PJ14099, 06ZR14098, and 06DZ22032), and the Chinese Academy of Sciences (KSCX2-YW-R-56 and 2007KIP204).
Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their overexpression can induce pluripotency in both mouse and human somatic cells, indicating that these factors...
关键词:embryonic stem cell PLURIPOTENCY Yamanaka factor signal pathway CHIP-ON-CHIP 
The genomic landscapes of histone H3-Lys9 modifications of gene promoter regions and expression profiles in human bone marrow mesenchymal stem cells被引量:7
《Journal of Genetics and Genomics》2008年第10期585-593,共9页Jiang Tan Hui Huang Wei Huang Lin Li Jianhua Guo Baiqu Huang Jun Lu 
the National Basic Research Program of China (No 2005CB522404 and 2006CB910506);the Program for Changjiang Scholars and Innovative Research Team (PCSIRT) in Universities (No IRT0519);the National Natural Science Founda-tion of China (No 30771232 and 30671184)
Mesenchymal stem cells (MSCs) of nonembryonic origins possess the proliferation and multi-lineage differentiation potentials. It has been established that epigenetic mechanisms could be critical for determining the ...
关键词:human bone marrow mesenchymal stem cells (MSCs) H3-Lys9 acetylation H3-Lys9 dimethylation CHIP-ON-CHIP MICROARRAY 
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