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Interferon-αstimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
《Military Medical Research》2025年第2期184-203,共20页Kai-Wei Jia Ren-Qi Yao Yi-Wen Fan Ding-Ji Zhang Ye Zhou Min-Jun Wang Li-Yuan Zhang Yue Dong Zhi-Xuan Li Su-Yuan Wang Mu Wang Yun-Hui Li Lu-Xin Zhang Ting Lei Liang-Chen Gui Shan Lu Ying-Yun Yang Si-Xian Wang Yi-Zhi Yu Yong-Ming Yao Jin Hou 
National Key Research and Development Program of China(2023YFC2505900);National Natural Science Foundation of China(92269204,82171755,92369106,82171749,82171811,82073184);Military Outstanding Youth Program(2020QN06119,01-SWK JYCJJ07,23SWAQ53);Program of Leading Talents in Shanghai,and Shanghai Shuguang Program(20SG39)。
Background Liver ischemia/reperfusion(I/R)injury is usually caused by hepatic inflow occlusion during liver surgery,and is frequently observed during war wounds and trauma.Hepatocyte ferroptosis plays a critical role ...
关键词:Ischemia/reperfusion(I/R) DExH-box helicase 58(DHX58) Glutathione peroxidase 4(GPX4) m6A modification YT521-B homology domain containing 2(YTHDC2) 
DNA methyltransferase 1/miR-342-3p/Forkhead box M1 signaling axis promotes self-renewal in cervical cancer stem-like cells in vitro and nude mice models
《World Journal of Stem Cells》2025年第3期44-64,共21页Xiao-Zheng Cao Yao-Feng Zhang Yu-Wei Song Lei Yuan Hui-Li Tang Jin-Yuan Li Ye-Bei Qiu Jia-Zhi Lin Ying-Xia Ning Xiao-Yu Wang Yong Xu Shao-Qiang Lin 
Supported by Guangzhou Basic and Applied Basic Research Foundation,No.202201010121;Medical Joint Fund of Jinan University,No.YXZY2024014 and No.YXJC2022001;Hospital Achievement Transformation and Cultivation Project,No.ZH201911;the Key Discipline Project of Guangdong Province,No.2019-GDXK-0016;and the Medical Science and Technology Research Foundation of Guangdong Province,No.B2021145.
BACKGROUND Cervical cancer(CC)stem cell-like cells(CCSLCs),defined by the capacity of differentiation and self-renewal and proliferation,play a significant role in the progression of CC.However,the molecular mechanism...
关键词:DNA methyltransferase 1 Cancer stem cell Cervical cancer MiR-342-3p Forkhead box M1 
谷物联合收获机清选装置参数监控与优化试验
《中国农机化学报》2025年第3期208-215,共8页陈新奇 耿令新 庞靖 黄胜操 王升升 林毅 
国家自然科学基金项目(52005163);河南省科技攻关项目(232102111120)。
为研究谷物联合收获机在不同喂入量下的最优参数组合,设计谷物联合收获机清选装置多参数监控系统。在此系统基础上,开展清选装置参数优化试验,研究清选装置参数对含杂率、损失率的影响规律,得到含杂率、损失率回归模型;取含杂率权重为0...
关键词:谷物联合收获机 清选装置 作业参数监控 喂入量 Plackett—Burman试验 Box—Behnken试验 
Boom Box 3遥爆系统与电子雷管在G3i仪器中的应用
《物探装备》2025年第1期49-51,共3页李伟利 蒋福罡 周成宽 邢永强 米辉 
本文详细介绍了Boom Box 3遥爆系统,MAXAM电子雷管与G3i仪器联机使用时编码器的改进与取得的市场成果;Boom Box 3编码器与G3i仪器硬件接口的连接方法和注意事项;Boom Box 3编码器译码器软件的关键参数设置及含义;G3i仪器的软件的关键参...
关键词:Boom Box3 G3i仪器 电子雷管 编译码器 
基于FPGA的雷达噪声信号设计与实现
《成都信息工程大学学报》2025年第1期29-35,共7页赵将冬 张福贵 汪治 
针对一些典型分布的噪声信号在雷达标定和信号处理中的实际需求,基于元胞自动机和Box-Muller算法提出一种在现场可编程门阵列上能够实时产生多种概率分布特性的噪声信号生成方法。首先将对数和三角函数序列存入只读存储器;然后使用两个3...
关键词:Box-Muller算法 瑞利分布 元胞自动机 现场可编程门阵列 高斯白噪声 
Enhancing box-wing design efficiency through machine learning based optimization
《Chinese Journal of Aeronautics》2025年第2期46-59,共14页Mehedi HASAN Azad KHANDOKER 
The funding for this publication was provided by Johannes Kepler University(JKU),Linz.Special thanks to Prof.Zongmin DENG from Beihang University for his invaluable guidance,insightful feedback,and constructive criticism,which greatly enhanced the quality of this manuscript.We extend our heartfelt gratitude to the PARSIFAL team for providing the supporting materials,which inspired this study.
The optimization of wings typically relies on computationally intensive high-fidelity simulations,which restrict the quick exploration of design spaces.To address this problem,this paper introduces a methodology dedic...
关键词:Box wing optimization Aerodynamic shape optimization Multi-objective optimization Machine learning Multi-fidelity method 
Exploring the mechanism of Xiaoaiping Injection inhibiting autophagy in prostate cancer based on proteomics
《Chinese Journal of Natural Medicines》2025年第1期64-76,共13页Qiuping Zhang Qiuju Huang Zhiping Cheng Wei Xue Shoushi Liu Yunnuo Liao Xiaolan Li Xin Chen Yaoyao Han Dan Zhu Zhiheng Su Xin Yang Zhuo Luo Hongwei Guo 
supported by Guangxi Natural Science Foundation(No.2023GXNSFDA026047);Guangxi Science and Technology Project(No.FANGKE ZY20221502);the National Natural Science Foundation of China(No.82160948);the Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University。
Xiaoaiping(XAP)Injection demonstrates the anti-prostate cancer(PCa)effects,yet the underlying mechanism remains unclear.This study aims to investigate the impact of XAP on PCa and elucidate its mechanism of action.PCa...
关键词:Xiaoaiping Injection AUTOPHAGY Apoptosis Forkhead box O3a Prostate cancer 
联合Marshall静脉无水酒精及二尖瓣峡部线性消融对持续性房颤“BOX”消融策略的作用
《四川医学》2025年第1期18-23,共6页龚倩 赖柱宏 何渠帅 李郁 杜薇 宋攀 罗彩东 黎东 
四川省卫生健康委员会医学科技项目(普及应用项目)(编号:21PJ179)。
目的评估联合肺静脉电隔离(PVI)及左房后壁电隔离的“BOX”消融策略基础上,进一步联合Marshall静脉(VOM)无水酒精消融及二尖瓣峡部线性消融能否提高持续性房颤射频消融手术的成功率。方法连续纳入2021年6月到2022年3月在我院行射频消融...
关键词:持续性房颤 Marshall静脉 左房后壁电隔离 二尖瓣峡部 
High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation
《Neural Regeneration Research》2025年第1期107-115,共9页Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi 
supported by a grant of the M.D.-Ph.D./Medical Scientist Training Program through the Korea Health Industry Development Institute(KHIDI);funded by the Ministry of Health&Welfare,Republic of Korea(to HK);supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT;Ministry of Science and ICT)(NRF2019R1A5A2026045 and NRF-2021R1F1A1061819);a grant from the Korean Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(HR21C1003);New Faculty Research Fund of Ajou University School of Medicine(to JYC)。
High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the ex...
关键词:central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 INFLAMMATION neural stem cells NEURODEVELOPMENT oligodendrocyte progenitor cells redox status REGENERATION 
Microstructure and mechanical properties of directly thixoforged complex box-shape 2A14 part with large wall-thickness difference
《Transactions of Nonferrous Metals Society of China》2024年第12期3876-3892,共17页Ying-ze LIU Ju-fu JIANG Ying ZHANG Min-jie HUANG Jian DONG Ying WANG 
supported by the National Key R&D Program of China(No.2022YFB3404204);the National Natural Science Foundation of China(No.U2241232);the Foundation of National Key Laboratory for Precision Hot Processing of Metals,China(No.6142909230203).
To form complex box-shape parts with large wall-thickness difference,a directly thixoforged technology of 2A14 alloy with low-cost and short-process was proposed and verified.The results showed that complex components...
关键词:THIXOFORGING microstructure mechanical properties 2A14 aluminum alloy 
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