OPTOGENETICS

作品数：74被引量：138H指数：7
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Prefrontal cortical circuits in anxiety and fear:an overview被引量：1
《Frontiers of Medicine》2022年第4期518-539,共22页Yihua Chen Nengyuan Hu Jianming Yang Tianming Gao 
supported by grants from the National Key R&D Program of China(No.2021ZD0202704 to Tianming Gao,No.2022ZD0214300 to Yihua Chen);the National Natural Science Foundation of China(Nos.82090032 and 31830033 to Tianming Gao);the Key Area Research and Development Program of Guangdong Province(Nos.2018B030334001 and 2018B030340001 to Tianming Gao);the Guangdong Basic and Applied Basic Research Foundation(No.2020A1515011310 to Yihua Chen);the Guangdong−Hong Kong−Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Fund(No.2019019 to Yihua Chen);the Science and Technology Program of Guangzhou(No.202007030013 to Tianming Gao).
Pathological anxiety is among the most difficult neuropsychiatric diseases to treat pharmacologically,and it represents a major societal problem.Studies have implicated structural changes within the prefrontal cortex(...
关键词：prefrontal cortex ANXIETY FEAR neural circuits OPTOGENETICS DREADD 
PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder
《Frontiers of Medicine》2019年第5期602-609,共8页Xiao He Chentao Jin Mindi Ma Rui Zhou Shuang Wu Haoying Huang Yuting Li Qiaozhen Chen Mingrong Zhang Hong Zhang Mei Tian 
We thank Prof.Binggui Sun for providing devices and laboratory space in virus injection, Binbin Nie for technical support in Statistical Parametric Mapping analysis and Qianyun Liu (Hopstem Biotechnology LLC) for technical support on immunostaining.Help from the Zhejiang University Intelligence Convergence was greatly appreciated.This work was supported by grants from the National Natural Science Foundation of China (No.81425015);the National Key Research and Development Program of China (No.2016YFA0100900);the National Natural Science Foundation of China (Nos.81725009, 81761148029, and 81571711);Zhejiang University K.P.Chao’s High Technology Development Foundation.
Panic disorder (PD) is an acute paroxysmal anxiety disorder with poorly understood pathophysiology. The dorsal periaqueductal gray (dPAG) is involved in the genesis of PD. However, the downstream neurofunctional chang...
关键词：PANIC DISORDER (PD) POSITRON emission tomography (PET) OPTOGENETICS DORSAL periaqueductal GRAY (dPAG) 
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