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support from the National Natural Science Foundation of China(21931010);the National Key R&D Program of China(grant No.2017YFA0207302).
A seven-step total synthesis of(+)-cylindricine D and epi-cylindricine D is described.The efficiency relies on the highly diastereoselective reductive bis-functionalization of N,O-protected(S)-pyroglutaminol by our re...
the Marie Skłodowska-Curie actions for an Individual Fellowship(V.C.,GA No.702385);the Leverhulme Trust for funding(H.G.G.,RPG-2015-003);the EPSRC for additional support(EP/S013172/1).
As products of genome mining,the stereochemical assignment of the macrolide antibiotics stambomycins A-D has been made on the basis of sequence analysis of the associated polyketide synthase,aside from two stereocentr...