Supported by the Key Research and Development Plan of Shaanxi Province,China,No.2018SF-265.
BACKGROUND Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis.Although the diphtheria-pertussis-tetanus vaccine is widely administered,there are still a number of patients with severe ...
Tumor lysis syndrome (TLS), hyperleukocytosis, and disseminated intravascular coagulation (DIC) are representative oncological emergencies that overlap mutually at the beginning of therapy for aggressive leukemia. Lat...
Leukocytosis or hyperleukocytosis occurs during ATRA or arsenic trioxide differentiation therapy, which is related to the RA syndrome. The number of WBC often increased by ten or more times as high as that of pretreat...
the National Natural Sciences Foundation of China (No. 39470318); and a grant from Science Committee of Shandong Province (No. 9
Objective: To detect the effect of arsenic trioxide or ATRA on APL cells or HL-60 cells and to investigate the mechanism of the hyperleukocytosis and detect the cross resistance between ATRA and arsenic trioxide. Meth...
Objective: To detect the G-CSF effect and its mechanism in hyperleucocytosis of patients with APL after treatment with all-trans retinoic acid (ATRA). Methods: MTT method was used to measure the proliferation of HL-60...
Objective: To detect the level of serum G-CSF. from patients with acute promyelocytic leukemia pre- or post-treatment with ATRA and analyze the relationship between serum G-CSF and hyperleukocytosis. Methods: Enzyme-l...