LACI

作品数:21被引量:26H指数:3
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相关作者:张宏达胡宝成于芳黄君健绳纪坡更多>>
相关机构:军事医学科学院第二军医大学温州医科大学吉林农业大学更多>>
相关期刊:《Science China(Life Sciences)》《微型计算机》《生物技术通讯》《黑龙江畜牧兽医》更多>>
相关基金:国家自然科学基金吉林省科技发展计划基金吉林省教育厅科学技术研究项目更多>>
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Design of trials in lacunar stroke and cerebral small vessel disease:review and experience with the LACunar Intervention Trial 2(LACI-2)
《Stroke & Vascular Neurology》2024年第6期581-594,共14页Gordon Blair Jason P Appleton Iris Mhlanga Lisa J Woodhouse Fergus Doubal Philip M Bath Joanna M Wardlaw 
Alzheimer Society UK.UK Dementia Research Institute(DRIEdi17/18MRC MC_PC_17113);British Heart Foundation(CS/15/5/31475);The Stroke Association.Mrs Gladys Row Fogo Charitable Trust(AD.ROW4.35D.FID3668413);Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces.Alzheimer’s Research UK.UK Medical Research Council.
Cerebral small vessel disease(cSVD)causes lacunar stroke(25%of ischaemic strokes),haemorrhage,dementia,physical frailty,or is‘covert’,but has no specific treatment.Uncertainties about the design of clinical trials i...
关键词:NARROW RETENTION MISSING 
TAG-Assisted Liquid-Phase Synthesis and Structure Activity Relationship of Macolacin-Based Side-to-Tail Cyclopeptides Antibiotic
《Chinese Journal of Chemistry》2024年第22期2728-2742,共15页Haidi Li Yuankui Jin Minfan Pei Linyan Zhang Lianjun Wang Yuxin Yang Peng Xiang Taigang Liang 
supported by the Shanxi Provincial Key Research and Development Project(202102130501004).
TAG-assisted peptide synthesis technology enables optimal conservation of Fmoc amino acid raw materials and chemical solvents while eliminating the need for intricate chromatographic purification processes.This work p...
关键词:Macolacin N-Methylation-modified Cyclopeptide antibiotics Antimicrobial activity Structure-activity relationship TAG-assisted peptide synthesis Peptide Antimicrobial agents 
Repeatability and reproducibility of corneal higher-order aberrations measurements after small incision lenticule extraction using the Scheimpfug-Placido topographer被引量:1
《Eye and Vision》2024年第1期1-9,共9页Rui Ning Rongrong Gao David PPiñero Jun Zhang Qingyi Gao Yili Jin Yiran Wang Chenxiao Wang Jinhai Huang 
the Medical and Health Science and Technology Program of Zhejiang Province(2019KY111);Foundation of Wenzhou City Science&Technology Bureau(Y2020037);EYE&ENT Hospital of Fudan University High-level Talents Program(2021318);Clinical Research Plan of SHDC(SHDC2020CR1043B)。
Background:To evaluate the precision of corneal higher-order aberrations measurements after small incision lenticule extraction(SMILE)using the Sirius Scheimpfug-Placido topographer(CSO,Italy).Methods:Seventy-fve eyes...
关键词:Sirius Higher-order aberrations REPEATABILITY REPRODUCIBILITY Small incision lenticule extraction 
Sirius Scheimpflug-Placido versus. ultrasound pachymetry for central corneal thickness: meta-analysis
《Eye and Vision》2023年第4期1-11,共11页Yili Jin Colm McAlinden Yong Sun Daizong Wen Yiran Wang Jinjin Yu Ke Feng Benhao Song Qinmei Wang Shihao Chen Jinhai Huang 
supported in part by the Foundation of Wenzhou City Science&Technology Bureau(Grant No.Y2020037);Medical and Health Science and Technology Program of Zhejiang Province(Grant No.2019KY111);Zhejiang Provincial&Ministry of Health Research Fund for Medical Sciences(Grant No.WKJ-ZJ-2134);Zhejiang Provincial High-level Talents Program(Grant No.2017-102).
Background:To compare the difference in central corneal thickness(CCT)measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer(Sirius,CSO,Italy)and ultrasound ...
关键词:META-ANALYSIS Central corneal thickness Scheimpflug-Placido topographer Ultrasound pachymetry 
Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease:baseline data and statistical analysis plan for the Lacunar Intervention Trial-2(LACI-2)(ISRCTN14911850)被引量:3
《Stroke & Vascular Neurology》2023年第2期134-143,共10页Philip M Bath Iris Mhlanga Lisa J Woodhouse Fergus Doubal Katherine Oatey Alan A Montgomery Joanna M Wardlaw LACI-Trial Investigators 
support for the research,authorship,and/or publication of this article:This work is supported by British Heart Foundation(CS/15/5/31475);the Alzheimer’s Society(AS-PG 14-033);EU Horizon 2020 SVDs@Target(666881);MRC UK DRI,Fondation Leducq(16/05 CVD);NHS Research Scotland,The Stroke Association and Garfield-Weston Foundation,Chief Scientist Office(UC);National Institute of Health Research.PMB is Stroke Association Professor of Stroke Medicine and an Emeritus NIHR Senior Investigator.
Background Cerebral small vessel disease(SVD)causes lacunar strokes(25%of all ischaemic strokes),physical frailty and cognitive impairment and vascular and mixed dementia.There is no specific treatment to prevent prog...
关键词:NITRATE initiated PREVENTION 
Correction:Cilostazol and isosorbide mononitrate for the prevention of progression of:baseline data and statistical analysis plan for the Lacunar Intervention Trial-2(LACI-2)(ISRCTN14911850)
《Stroke & Vascular Neurology》2023年第2期I0001-I0001,共1页
Bath PM,Mhlanga I,Woodhouse LJ,et al.Cilostazol and isosorbide mononitrate for the prevention of progression of:baseline data and statistical analysis plan for the Lacunar Intervention Trial-2(LACI-2)(ISRCTN14911850)....
关键词:nitrate DETAILS PREVENTION 
基于大肠杆菌的重离子辐射靶点序列定位和LacI突变分析的实验体系构建及验证
《原子核物理评论》2023年第1期113-120,共8页金铭 王婷 刘斌美 卞坡 
国家自然科学基金资助项目(12135016)。
重离子辐射具有独特的物理和生物学特性,在诱变育种等领域有着广泛的应用,但其诱变的机制并不完全清楚。不同于传统的X和γ射线,重离子辐射具有较高的线传能密度(Linear energy transfer,LET),主要诱导团簇状的DNA损伤,其演化为遗传变...
关键词:重离子 γ 射线 同源重组 团簇损伤 
LipR functions as an intracellular pH regulator in Bacillus thuringiensis under glucose conditions
《mLife》2023年第1期58-72,共15页Xia Cai Jiaxin Qin Xuelian Li Taoxiong Yuan Bing Yan Jun Cai 
supported by the National Key Research and Development Program of China(2018YFA0900100);the National Natural Science Foundation of China(31670081).
Intracellular pH critically affects various biological processes,and an appropriate cytoplasmic pH is essential for ensuring bacterial growth.Glucose is the preferred carbon source for most heterotrophs;however,excess...
关键词:GLUCOSE intracellular pH LacI‐type transcription factor LipR 
饮用水中大肠埃希菌双重PCR检测方法建立被引量:4
《中国公共卫生》2021年第3期574-576,共3页刘艳超 王荣敏 谢佳鑫 王明晓 
内蒙古医科大学实验室开放基金(2017KF06);内蒙古医科大学教改资助(NYJXGG2017028)。
目的建立饮用水大肠埃希菌的双重PCR检测方法,并评价效果。方法选取大肠埃希菌的保守序列16SrRNA基因E-16SrDNA和乳糖操纵子LacI基因序列E-LACI作为双重PCR方法的两段扩增基因,根据GenBank上已知序列设计合成两段基因引物,使用大肠埃希...
关键词:大肠埃希菌 双重PCR 饮用水检验 16Sr RNA 乳糖操纵子(LacI) 
Sirius Scheimpflug–Placido versus ultrasound pachymetry for central corneal thickness:meta-analysis被引量:2
《Eye and Vision》2021年第1期36-46,共11页Yili Jin Colm McAlinden Yong Sun Daizong Wen Yiran Wang Jinjin Yu Ke Feng Benhao Song Qinmei Wang Shihao Chen Jinhai Huang 
supported in part by the Foundation of Wenzhou City Science&Technology Bureau(Y2020037);Medical and Health Science and Technology Program of Zhejiang Province(2019KY111);Zhejiang Provincial&Ministry of Health Research Fund for Medical Sciences(WKJ-ZJ-2134);Zhejiang Provincial High-level Talents Program(2017–102).
Background:To compare the difference in central corneal thickness(CCT)measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer(Sirius,CSO,Italy)and ultrasound ...
关键词:META-ANALYSIS Central corneal thickness Scheimpflug-Placido topographer Ultrasound Pachymetry 
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