云南高校图书馆联盟文献共享服务平台- AEROLYSIN

AEROLYSIN: 作品数：11被引量：30H指数：5; 导出分析报告; 相关领域：生物学农业科学更多>>; 相关作者：龙亿涛应佚伦龙亿涛曹婵廖冬芳更多>>; 相关机构：华东理工大学南京大学中国科学院大学江南大学更多>>; 相关期刊：《分析测试学报》《Science China Chemistry》《Marine Life Science & Technology》《化学学报》更多>>; 相关基金：国家自然科学基金高等学校学科创新引智计划上海市教育发展基金会晨光计划项目更多>>

基于Aerolysin纳米孔道的单个β-淀粉样多肽N-端片段分析: 《高等学校化学学报》2024年第11期200-208,共9页陈天泽胡方舟林绪波应佚伦邹爱华; 国家自然科学基金(批准号:22334006)资助。; 淀粉样蛋白(β-amyloid,Aβ)引起的淀粉样蛋白异常沉积被认为是诱发阿尔茨海默症的因素之一.与人类不同,啮齿动物较少出现这类特征性病变.与人类Aβ相比,啮齿动物Aβ的第5,10和13位氨基酸由Arg,Tyr和His分别变为Gly,Phe和Arg.本文采用...; 关键词：Β-淀粉样蛋白气单胞菌溶素多肽单分子分析生物纳米孔道

Pichia pastoris composition expressed aerolysin mutant of Aeromonas veronii as an oral vaccine evaluated in zebrafish(Danio rerio): 《Marine Life Science & Technology》2024年第3期475-487,共13页Yuan-Yuan Yao Qing-Shuang Zhang Shu-Bin Liu Hong-Wei Yang Xing-Yu Chen Ya-Lin Yang Chen-Chen Gao Chao Ran Tsegay Teame Zhen Zhang Zhi-Gang Zhou; funded by National Natural Sci-ence Foundation of China(NSFC 32303027);Agricultural Science and Technology Innovation Program(ASTIP)and Basal Research Fund(1610382023017)of the Chinese Academy of Agricultural Sciences;Project Team of Foshan National Hi-tech Industrial Development Zone Industrialization Entrepreneurial Teams Program(2320197000012);Beijing Innovation Consortium of Agriculture Research System(BAIC07-2023-11).; Vaccines are one of the most practical means to stop the spreading of Aeromonas veronii in aquaculture.In this study,virulence factor aerolysin mutant NTaer which has lost its hemolytic activity was used as a target a...; 关键词：Aeromonas veronii Aerolysin mutant NTaer Oral vaccine Immune response Gut microbiota

Structural characteristics and the label-free detection of poly(3,4-ethylenedioxythiophene/cucurbit[7]uril)pseudorotaxane at single molecule level: 《Nano Research》2023年第2期2728-2737,共10页Aurica Farcas Hadjer Ouldali Corneliu Cojocaru Manuela Pastoriza-Gallego Ana-Maria Resmerita Abdelghani Oukhaled; supported by a grant of the Ministry of Research,Innovation and Digitization,CNCS–UEFISCDI,project number PN-III-P4-PCE-2021-0906;within PNCDI III and the Institute desÉtudes Avancées(IEA)of Cergy-Pontoise University(Project INEX“Pi-ROT”#73).; A multi-technique approach to prove the preparation of poly(3,4-ethylenedioxythiophene/cucurbit[7]uril)pseudorotaxanes(PEDOT∙CB7-PPs)is reported.Molecular docking simulation and matrix-assisted laser desorption/ioniza...; 关键词：supramolecular encapsulation poly(3 4-ethylenedioxythiophene)(PEDOT) uril AEROLYSIN electrical detection computational modeling

Aerolysin纳米孔核酸检测灵敏区域的协同相互作用探索研究被引量：6: 《化学学报》2019年第10期984-988,共5页李孟寅应佚伦龙亿涛; 国家自然科学基金(Nos.21834001,61871183)资助~~; 纳米孔单分子检测技术以其简便、快速、高通量及无需标记等特点,应用于DNA及蛋白质测序,更有望实现单分子动态构象变化的研究. Aerolysin(气单胞菌溶素)纳米孔道由于其特有的较长的β-桶限域区(β-barrel)及孔内壁丰富的带电荷氨基酸残...; 关键词：纳米孔单分子界面电化学限域气单胞菌溶素寡聚核苷酸

基于Aerolysin纳米孔道对单个c-di-AMP分子的检测研究被引量：5: 《化学学报》2019年第10期989-992,共4页牛红艳胡正利应佚伦龙亿涛; 国家自然科学基金(Nos.21922405,61871183,21834001);国家“万人计划”青年拔尖人才资助~~; 环二腺苷酸(c-di-AMP)是原核细胞中普遍存在的第二信使,不仅能够有效调控细胞生长、离子转运、细胞壁代谢平衡等多种生理过程,还能引发I型干扰素应答,激发机体天然免疫反应.本实验使用单个气单胞菌溶素(Aerolysin)纳米孔道蛋白构建的单...; 关键词：环二腺苷酸环二核苷酸气单胞菌溶素单分子界面生物纳米孔道

Aerolysin单分子界面的构建及高选择性单分子检测被引量：5: 《高等学校化学学报》2019年第9期1825-1831,共7页武雪原应佚伦龙亿涛; 国家自然科学基金(批准号:21834001,61871183)资助~~; 提出了一种基于Aerolysin膜蛋白质分子构建单分子界面的方法,运用蛋白质工程技术对单分子界面进行定点修饰,所建立方法灵活、可控且重复性好.采用Poly(dA)4为探针分子对修饰后的单分子界面进行了表征,结果表明,在孔口处的Arginine修饰...; 关键词：气单胞菌溶素单分子界面纳米孔道单分子分析

Aerolysin Nanopore Identification of Single Nucleotides Using the AdaBoost Model被引量：3: 《Journal of Analysis and Testing》2019年第2期134-139,共6页Xue-Jie Sui Meng-Yin Li Yi-Lun Ying Bing-Yong Yan Hui-Feng Wang Jia-Le Zhou Zhen Gu Yi-Tao Long; This research was supported by the National Natural Science Foundation of China(6187118,2183400 and 21711530216);the“Chen Guang”project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation(17CG27).; Nanopores employ the ionic current from the single molecule blockage to identify the structure,conformation,chemical groups and charges of a single molecule.Despite the tremendous development in designing sensitive po...; 关键词：Nanopore single nucleotide discrimination Single molecule analysis ADABOOST Hidden Markov model

Precise Construction and Tuning of an Aerolysin Single-Biomolecule Interface for Single-Molecule Sensing被引量：1: 《CCS Chemistry》2019年第3期304-312,共9页Xue-Yuan Wu Ming-Bo Wang Ya-Qian Wang Meng-Yin Li Yi-Lun Ying Jin Huang Yi-Tao Long; This research was supported by the National Natural Science Foundation of China(21834001 and 61871183);Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-02-E00023).; Membrane protein molecules can self-assemble to form a single-biomolecule interface,which can accommodate one single molecule at a time and provide a suitable sensing environment for single-molecule measurements.To ac...; 关键词：single-biomolecule interface AEROLYSIN single-molecule analysis site-directed mutagenesis nanopore sensor

Aerolysin蛋白纳米孔道直接检测单个DNA碱基修饰被引量：5: 《分析测试学报》2019年第2期129-133,共5页路瑶胡正利应佚伦龙亿涛; 国家自然科学基金资助项目(21421004);上海市"晨光计划"项目(17CG27); 基于Aerolysin生物膜通道蛋白的纳米孔道电化学分析技术,因其高的电化学空间限域能力可实现超灵敏DNA单分子检测。本文利用单个Aerolysin纳米孔道在无需标记、无需扩增的条件下直接分辨3种具有单个碱基差异的单链DNA。实验结果显示,具...; 关键词：生物纳米孔道单分子分析 DNA 电化学空间限域

Monitoring disulfide bonds making and breaking in biological nanopore at single molecule level被引量：2: 《Science China Chemistry》2018年第11期1385-1388,共4页Bing Zhou Ya-Qian Wang Chan Cao Da-Wei Li Yi-Tao Long; supported by the National Natural Science Foundation of China (21421004, 21777041, 21327807);the Program of Introducing Talents of Discipline to Universities (B16017);Innovation Program of Shanghai Municipal Education Commission (2017-0107-00-02-E00023);the Fundamental Research Funds for the Central Universities (222201718001, 222201717003); Monitoring subtle changes in ionic current flow through a nanopore could be applied to observe single molecule reaction. Here,we introduced cysteine to substitute for lysine at position 238 constructing a mutant aerol...; 关键词：disulfide bond chemical bond making and breaking aerolysin nanopore single molecule level

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