supported by grants from the National Key Research and Development Program of China(2018YFA0800403 and 2021YFC2701903);the Training Program of the Major Research Plan of the National Natural Science Foundation of China(91857110);the National Natural Science Foundation of China(81670740,32000817,82100904,and 82300910);the National Natural Science Fund for Excellent Young Scholars of China(81722012);the Zhejiang Provincial Natural Science Foundation of China(LZ21H070001,LHDMD22H02001,and LHDMD24H030001);the Innovative Institute of Basic Medical Sciences of Zhejiang University,and the Fundamental Research Funds for the Central Universities.
Skeletal muscle plays a vital role in the regulation of systemic metabolism,partly through its secretion of endocrine factors which are collectively known as myokines.Altered myokine levels are associated with metabol...