AGGRECANASE

作品数：5被引量：25H指数：3
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相关领域：医药卫生更多>>
相关作者：李静雅叶其壮杨少华张博李增新更多>>
相关机构：中国科学院桂林医学院附属医院北华大学更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《生物化学与生物物理进展》《Journal of Pharmaceutical Analysis》更多>>
相关基金：国家自然科学基金更多>>
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Action Mechanisms of Complementary and Alternative Medicine Therapies for Rheumatoid Arthritis被引量：1
《Chinese Journal of Integrative Medicine》2011年第10期723-730,共8页Imada Keisuke 边宝林 李向东 Sato Takashi Ito Akira 
Rheumatoid arthritis （RA） is characterized as a chronic inflammatory disease in joints and concomitant destruction of cartilage and bone. Cartilage extracellular matrix components, such as type Ⅱ collagen and aggre...
关键词：rheumatoid arthritis extracellular matrix AGGRECANASE matrix metalloproteinase complementary and alternative medicine 
Effects of RNAi-mediated inhibition of aggrecanase-1 and aggrecanase-2 on rat costochondral chondrocytes in vitro被引量：4
《Acta Pharmacologica Sinica》2008年第10期1215-1226,共12页Zheng-hui WANG Zhuang-qun YANG Xi-jing HE Li WANG Li-xia LI Jun-bo TU 
This study was supported by the National Natural Science Foundation of China （No 30572052） and the International Cooperation Project of Shaan＇xi Province, China （No 2007KW-07）. Acknowledgement The excellent technical assistance of Jian-feng SHI （Research Center of Stomatological Hospital） is gratefully acknowledged.Author contribution Zhuang-qun YANG, Xi-jing HE, Zheng-hui WANG, Li WANG, and Li-xia LI designed research; Zheng-hui WANG performed research; Zheng-hui WANG, Li WANG, and Li-xia LI analyzed data; Zheng-hui WANG and Jun-bo TU wrote the paper.
Aim： Failure of transplanted cartilage or allogenic chondrocytes is attributed mainly to immunological rejection and cartilage degradation. A major feature is the loss of aggrecan from the cartilage matrix, primarily...
关键词：AGGRECANASE CHONDROCYTE AGGRECAN RNAi extracellular matrix 
Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect被引量：16
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2008年第1期22-33,共12页Si-yuan LI Jun-ling CAO Zhong-li SHI Jing-hong CHEN Zeng-tie ZHANG Clare E. HUGHES Bruce CATERSON 
Project supported by the National Natural Science Foundation of China (Nos. 30471499 and 30170831);the Ministry of Education of China (No.Key 03152);the Science Foundation of Shaanxi Province of China (No.2004KW-20)
Objective: To identify the relationship between T-2 toxin and Kashin-Beck disease (KBD),the effects of T-2 toxin on aggrecan metabolism in human chondrocytes and cartilage were investigated in vitro. Methods: Chondroc...
关键词：T-2 toxin Kashin-Beck disease （KBD） AGGRECAN IL-1β TNF-α AGGRECANASE Hyaluronic acid （HA） CD44 
THE EFFECT ON PROTEOGLYCAN METABOLISM OF DEOXYNIVALENOL AND SELENIUM IN THE CULTURED HUMAN FETAL CHONDROCYTES IN VITRO
《Journal of Pharmaceutical Analysis》2005年第2期57-60,共4页岳燕 曹峻岭 李思远 谢龙 孙健 张增铁 张富军 师钟丽 
ThisstudywassupportedbytheNationalNaturalScienceFoundationofChina(No.30170831)andtheKeyTechnologicalReseachItemofEducationMinistry(No.03152)
Objective To investigate the effect of deoxynivalenol (DON) and selenium (Se) on the morphology of chondrocytes and the metabolism of cartilage matrix, and the expression of aggrecanase-1, 2 mRNA in monolayer cultured...
关键词：kashin-beck disease (KBD) bone matrix gelatin (BMG) deoxynivalenol (DON) selenium(Se) NITEGE epitope AGGRECANASE 
治疗关节炎症的新靶点——聚蛋白多糖酶Aggrecanase的研究进展被引量：4
《生物化学与生物物理进展》2001年第5期654-657,共4页李静雅 叶其壮 
聚蛋白多糖酶 (aggrecanase)是新发现的降解软骨组织重要成分聚蛋白多糖 (aggrecan)的金属蛋白酶 ,是治疗关节炎的新靶点 .Aggrecanase的发现使得关节炎的治疗有望取得新的突破 ,为能从根本上治疗和预防关节炎提供了基础 .综述了aggreca...
关键词：聚蛋白多糖酶 关节炎 聚蛋白多糖 基质金属蛋白酶 酶抑制剂 治疗 靶点 
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