We would like to acknowledge financial supports by the National Natural Science Foundation(81430025,81701265,31800898,U801681);Acknowledgements are also to the supports of the Swedish Research Council(K2015-61X-22297-03-4);EU-JPND(aSynProtec),EU-JPND(REfrAME),EU H2020-MSCA-ITN-2016(Syndegen),BAGADILICO-Excellence in Parkinson and Huntington Research,the Strong Research Environment MultiPark(Multidisciplinary research on Parkinson’s disease),the Swedish Parkinson Foundation(Parkinsonfonden),Torsten Söderbergs Foundation,Olle Engkvist Byggmästere Foundation;W.L.is supported by a scholarship from the China Scholarship Council;TFO is supported by the DFG Center for Nanoscaly Microscopy and Molecular Physiology of the Brain(CNMPB).
Background:Progressive accumulation ofα-synuclein is a key step in the pathological development of Parkinson’s disease.Impaired protein degradation and increased levels ofα-synuclein may trigger a pathological aggr...