ANTI-LEUKEMIA

作品数：8被引量：6H指数：2
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相关领域：医药卫生更多>>
相关作者：彭咏波刘群李萍更多>>
相关机构：中国药科大学更多>>
相关期刊：《China Medical Abstracts(Internal Medicine)》《中国药理学通报》《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金更多>>
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Preparation of a novel tri-specific T cell engager targeting CD19 antigen and its anti-leukemia effect exploration
《China Medical Abstracts(Internal Medicine)》2021年第3期185-185,共1页CHEN Manling 
Objective To prepare a novel tri-specific T cell engager(19TriTE)targeting CD19 antigen,and to investigate its immunotherapeutic effect on CD19-positive hematological malignancies.Methods 19TriTE was construeted by mo...
关键词：CD19 EFFECT LEUKEMIA 
Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity被引量：3
《Chinese Journal of Natural Medicines》2021年第7期528-535,共8页YAN Chen LONG Qun ZHANG Yun-Dong BABU Gajendran KRISHNAPRIYA Madhu Varier QIU Jian-Fei SONG Jing-Rui RAO Qing YI Ping SUN Mao LI Yan-Mei 
supported by the Science and Technology Department of Guizhou Province(No.QKHJC[2016]1002,81872772,81960546,and U1812403);the National Natural Science Foundation of China(Nos.81872772,81960546,and U1812403);the Science and Technology Department of Anshun City(No.ASKP[2019]3);the 100 Leading Talents of Guizhou Province(fund for LI Yan-Mei,Nos.P2018-KF11 and QZYY-019-022).
In this study,three new germacranolide sesquiterpenes(1–3),together with six related known analogues(4–9)were isolated from the whole plant of Carpesium cernuum.Their structures were established by a combination of ...
关键词：Carpesium cernuum Germacranolides ANTI-LEUKEMIA K562 MAPK 
Scientists Provide A New Option for Anti-Leukemia Therapy
《Bulletin of the Chinese Academy of Sciences》2019年第2期117-118,共2页
RNA epitranscriptomics, the study of chemical modifications to RNA or the transcriptome (the entirety of RNA in a cell), represents a recently identified layer of regulation of genetic information. As the most abundan...
关键词：study RNA PROCESSES 
Total Saponins of Rubus Parvifolius L.Exhibited Anti-Leukemia Effect in vivo through STAT3 and eIF4E Signaling Pathways被引量：2
《Chinese Journal of Integrative Medicine》2018年第12期920-924,共5页XU Xiao-feng CHENG Ru-bin ZHANG Xue-jin GAO Rui-lan 
Supported by grants from Zhejiang Provincial Administration of Traditional Chinese Medicine(No.2011ZA081,No.2012ZB120,No.2013ZB095 and No.2014ZB089);Hangzhou Medical Science and Technology Plan(No.2012A048)
Objective： To investigate the anti-leukemia effect of total saponins of Rubus parvifo/ius L. （TSRP） on K562 cell xenografts in nude mice and the mechanisms of action. Methods： The K562 cell xenografts in nude mice...
关键词：total saponins of Rubus parvifolius L. xenograft model APOPTOSIS signal transducer and activator of transcription 3 eukaryotic initiation factor 4E 
In vitro antileukemia activity of ZSTK474 on K562 cells
《中国药理学通报》2015年第B11期234-235,共2页
Aim Chronic myelogenous leukemia （CML） is a hematopoietic stem cell cancer caused by the Bcr-Abl tyrosine kinase which arises from Philadelphia chromosome （Ph） translocation. Imatinib showed potent antitumor effic...
关键词：ANTI-LEUKEMIA ZSTK474 K562 K562/ADR cells cell cycle ARREST PI3K INHIBITOR 
Synthesis and Anti-leukemia Evaluation of Tetrahydro-4H-pyrano[3,2-c]pyridines and Corresponding Anti-CD14 Monoclonal Antibody Conjugates
《Chemical Research in Chinese Universities》2013年第6期1104-1109,共6页SUN Chuan-wen WANG Jing PANG Chun-cheng LI Jing XIAO Di 
the ＂Twelfth Five-Year＂ National Science and Technology Support Program，the National Natural Science Foundation of China，the Innovation Project of Shanghai Education Commission,China，the Leading Academic Discipline Project of Shanghai Normal University,China
A series of novel tetrahydro-4H-pyrano[3,2-c]pyridines（3a-3p） were synthesized and found to possess potent antiproliferative activity against leukemia K562 cells in vitro. Preliminary bioassay indicates that compoun...
关键词：Tetrahydro-4H-pyrano[3 2-c]pyridine Leukemia K562 cell Anti-CDl4 monoclonal antibody（McAb） Conjugate Inhibitory Toxicity 
N-（Substituted benzyl）-3,5-bis（benzylidene）-4-piperidones： Synthesis and Preliminary Anti-leukemia Activity （I）被引量：1
《Chinese Journal of Chemistry》2011年第10期2109-2113,共5页王静 孟雯 倪振杰 薛思佳 
A series of novel N-（substituted benzyl）-3,5-bis（benzylidene）-4-piperidones 5a--50 were synthesized with substituted benzylamines as raw materials via a series of Michael addition, Dieckmann condensation, hydrolys...
关键词：4-piperidone SYNTHESIS inhibition leukemia K562 cell MTT 
Specific induction of anti-leukemia effects by umbilical cord cell-derived CD8^+ T cytotoxic lymphocytes
《China Medical Abstracts(Internal Medicine)》2006年第4期225-226,共2页刘芯 
Objective To explore the specific anti-leukemia immune response of CD8+ cytotoxic T lymphocyte (CTL) derived from cord blood (CB) ex vivo and evaluate the feasibilities and values of the CTL for specific immunotherapy...
关键词：cytotoxic UMBILICAL INDUCTION immunotherapy lymphocyte LYSATE TETRAZOLIUM MONONUCLEAR thiazolyl cytokines 
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