supported by National Natural Science Foundation of China (No.81901535 and No.82071698);the National Key Research&Developmental Program of China (No.2021YFC2700203);Natural Science Foundation of Beijing Municipality (No.7222208).
Spermatogenesis is regulated by several Y chromosome-specific genes located in a specific region of the long arm of the Y chromosome,the azoospermia factor region(AZF).AZF microdeletions are the main structural chromo...
The aim of the present work was to present the outcomes of the patients with Y-chromosome microdeletions treated by intracytoplasmic sperm injection (ICSI), either using fresh (TESE) or frozen-thawed (TESE-C) te...
Maturation arrest (MA) refers to failure of germ cell development leading to clinical nonobstructive azoospermia. Although the azoospermic factor (AZF) region of the human Y chromosome is clearly implicated in som...
Infertility in humans is surprisingly common occurring in approximately 15% of the population wishing to start a family. Despite this, the molecular and genetic factors underlying the cause of infertility remain large...
Since the introduction of intracytoplasmic sperm injection (ICSI) using single sperm isolated from testicular tissue in men with obstructive and non-obstructive azoospermia, or using ejaculated sperm in those with p...
ACKNOWLEDGMENTS This research was supported by the Major State Basic Research Development Program of China (973 Program, Noso 2006GB504005 and 2009CB941700), the National Natural Science Foundation of China (No. 30872765) and the Basic Research Key Program of Shanghai (10]C1410800). Shi-Wei Duan is sponsored partly by the K. C. Wong Magna Fund of Ningbo University. Wethank Dr Ching-Ling Chen for kind suggestions regarding English in drafting this paper.
Multiplex polymerase chain reaction (PCR) has been widely used to detect Y-chromosome micredeletions, which is one of the major causes of male infertility. Both the European Academy of Andrology (EAA) and the Euro...
Objective: To study the relationship between relevant gene micro-deletion and spermatogenesis in infertile men. Methods: To analyze the relevant genes of the Y-chromosome and the karyotype of peripheral blood chromoso...