PHARMACOKINETICS/PHARMACODYNAMICS

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TCP-1,a novel peptide to diagnose early colon cancer
《Chinese Chemical Letters》2024年第3期226-233,共8页Hang Yu Baoying Wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen Zhang Yan Li Chi-Hin Cho Chongjing Zhang Xiaoguang Chen Yan Wang 
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-027);National Natural Science Foundation of China(Nos.T2192972,81402997);Key Project of Beijing Natural Science Foundation(No.7181007);National High-tech Research and Development Plan(863 Plan,No.2014AA020803);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study(No.Z141102004414062)。
A nine cyclic peptide(TCP-1)showed excellent specificity for colon cancer.TCP-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagno...
关键词：Colon cancer TCP-1 PEPTIDE Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD) 
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