supported by the Thousand Young Talents Program of China;the National Natural Science Foundation of China(31770795,81974514,21961003;31971043);the Jiangxi Provincial Natural Science Foundation(20181ACB20014 and20192BAB205114);the Open Project of Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Ministry of Education(XN201904);Gannan Medical University(QD201910);Jiangxi"Double Thousand Plan";the Foreign Talent Project of Jiangxi Province;Talent Project of Jiangxi Province;Shenzhen Fundamental Research Program;Ganzhou COVID-19 Emergency Research Project。
Almost everyone is susceptible to the severe acute respiratorysyndrome coronavirus 2(SARS-CoV-2),an RNA virus,which cancause many symptoms and even death among high-risk individu-als[1,2].The main protease(M^(Pro),als...