SHIKONIN

作品数:40被引量:150H指数:7
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Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode被引量:9
《Science Bulletin》2021年第7期661-663,M0003,共4页Jian Lia Xuelan Zhou Yan Zhang Fanglin Zhong Cheng Lin Peter J.McCormick Feng Jiang Jun Luo Huan Zhou Qisheng Wang Yang Fu Jingjing Duan Jin Zhang 
supported by the Thousand Young Talents Program of China;the National Natural Science Foundation of China(31770795,81974514,21961003;31971043);the Jiangxi Provincial Natural Science Foundation(20181ACB20014 and20192BAB205114);the Open Project of Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Ministry of Education(XN201904);Gannan Medical University(QD201910);Jiangxi"Double Thousand Plan";the Foreign Talent Project of Jiangxi Province;Talent Project of Jiangxi Province;Shenzhen Fundamental Research Program;Ganzhou COVID-19 Emergency Research Project。
Almost everyone is susceptible to the severe acute respiratorysyndrome coronavirus 2(SARS-CoV-2),an RNA virus,which cancause many symptoms and even death among high-risk individu-als[1,2].The main protease(M^(Pro),als...
关键词:小分子抑制剂 紫草素 冠状病毒 药物研发 药物靶点 天然产物 中药活性成分 结合模式 
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