funded by the National Natural Science Foundation of China(32071921);Key R&D Program of Shandong Province,China(2021LZGC022);Taishan Scholars Project(ts201712024).
Arogenate dehydratase(ADT)catalyzes the final step in phenylalanine synthesis and is crucial for plant development and metabolism.Previously,we demonstrated that the ADT/prephenate dehydratase ZmADT2 is essential for ...
supported in part by grants from the National Key Research and Development Program of China(2022YFC2303100 for L.P and W.L);the National Natural Science Foundation of China(32030002 and 22193070 for W.L);the Science and Technology Commission of Shanghai Municipality(20XD1425200 for L.P);the CAS Youth Interdisciplinary Team(JCTD-2022-10 for L.P).
Dehydration of serine/threonine residues necessitates the activity of a dehydratase enzyme(domain)during the biosynthesis of RiPP.Recently,it was reported that dehydration in the thioviridamide pathway relies on a dis...
Fishes are excellent markers of the extent of pollution from heavy metals in aquatic environments given that they are found at various levels of the food chain.This study aimed to investigate the bioaccumulation of he...
Organoseleniums are a class of compounds attracting attention across the globe owing to their Glutathione peroxidase(GPx)mimicry,which confers on them a strong antioxidant activity.Diphenyl diselenide(DPDS)is an Organ...
This work was supported by grants from the National Natural Science Foundation of China(32122080,31972375,31902049);Shandong Province(ZR2020YQ25).
Ethylene-mediated leaf senescence and the compromise of photosynthesis are closely associated but the underlying molecular mechanism is a mystery.Here we reported that apple DEHYDRATASE-ENOLASE-PHOSPHATASE-COMPLEX1(Md...
supported by grants from the National Key Research and Development Program of China(2018YFD1000200);the National Natural Science Foundation of China(31972375);the Ministry of Agriculture of China(CARS-28);Shandong Province(SDAIT-06-03);Nanjing Agricultural University(ZW201805).
Basic helix−loop−helix(bHLH)domain-containing transcription factors are known for their roles in regulating various plant growth and developmental processes.Previously,we showed that MdbHLH3 from apple(Malus domestica...
This work was supported by the grant from the National Natural Science Foundation of China(No.21602243).
Microbial natural products have always performed a prominent role in the history of drug discovery and development[1].These secondary metabolites have a remarkable range of biological activities which are mainly cause...
Acknowledgments This project was supported by the National Natural Science Foundation of China (21572133 to LZ, 21210003 to HJ and 91413102 to XS), the Program for Professors of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning (to LZ), the National Great Basic Science Project of China (2010CB529806 to HC), the Ministry of Science and Tech- nology of China (2015CB910304 to HJ). We thank the staff of beamlines BL19U 1 and BL19U2 at the National Center for Protein Sciences Shanghai (NCPSS) and Shanghai Synchrotron Radiation Facility (SSRF, China) for assistance with crystal diffraction and SAXS data collection. We thank professors Jianping Ding and Ji- ainu Du from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences for data analysis and discussion. We thank Mr Jing Lan from WYATT Technology for SEC-MALS technical support, Mr Fenfei Wang from Quantum Design China & Nano- Temper Technologies GmbH for MST technical support, and Dr Jos6 Ramdn Andrade Candelario for production of the animation (http://www.3 dciencia.com/).
Fatty acid biosynthesis (FAS) is a vital process in cells. Fatty acids are essential for cell assembly and cellular meabolism. Abnormal FAS directly correlates with cell growth delay and human diseases, such as meta...
Anthocyanins, a group of L-phenylalanine (Phe)-derived flavonoids, have been demonstrated to play impor- tant roles in plant stress resistance and interactions between plants and insects. Although the anthocyanin bi...
Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobac- terium tuberculosis (Mtb). Consequently, stalling dehy-dration cures tuberculosis (TB). Clinically us...