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Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report
《Frontiers of Medicine》2025年第1期170-173,共4页Xiaotong Qiu Liangkun You Chongwei Wang Jin Sheng 
SMARCA4-deficient non small cell lung cancer (SMARCA4-dNSCLC) has recently garnered increasing attention due to its high malignancy and poor prognosis. The literature suggests that in non small cell lung cancer (NSCLC...
关键词：SMARCA4-dNSCLC rare EGFR mutations targeted therapy case report 
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation被引量：1
《Frontiers of Medicine》2024年第5期831-849,共19页Shubei Chen Dianjia Liu Bingyi Chen Zijuan Li Binhe Chang Chunhui Xu Ningzhe Li Changzhou Feng Xibo Hu Weiying Wang Yuanliang Zhang Yinyin Xie Qiuhua Huang Yingcai Wang Stephen DNimer Saijuan Chen Zhu Chen Lan Wang Xiaojian Sun 
supported by the Center for High Performance Computing at Shanghai Jiao Tong University;supported by the National Key R&D Plan of China(No.2018YFA0107802 to Xiaojian Sun,Nos.2018YFA0107200 and 2018YFA0800203 to Lan Wang);the National Natural Science Foundation of China General Program(Nos.81970150 and 82170156 to Lan Wang);Shanghai“Science and Technology Innovation Action Plan”Excellent Academic/Technical Leader Program(Youth)(No.21XD1424500 to Lan Wang);Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01 to Saijuan Chen and Xiaojian Sun);Samuel Waxman Cancer Research Foundation,and the Shanghai Guangci Translational Medical Research Development Foundation.
SETD2 is the only enzyme responsible for transcription-coupled histone H3 lysine 36 trimethylation(H3K36me3).Mutations in SETD2 cause human diseases including cancer and developmental defects.In mice,Setd2 is essentia...
关键词：Setd2 H3K36 methylation EPIGENETICS embryonic development cancer 
A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t（8;14）（q24;q32） translocation
《Frontiers of Medicine》2018年第3期324-329,共6页Xiaofeng Shi Rong Ba Haiyan You Qian Jiang Jiansong Huang Jianhua Mao Lanxiu Han Shuo Zhang Qin Zhuang Xianqiu Yu Lixia Wang Yun Wang Dongya Li Wei Zhu Yong Zhang Yan Zhu Xiaodong Xi 
This work was supported in part by grants from National Natural Science Foundation of China （No. 81670127） and Natural Science Foundation of Jiangsu Province （No. BK20150474）, and Xiaofeng Shi is a member of medical key personnel of Zhenjiang Municipality and young medical personnel of Jiangsu Province.
Splenic lymphoma with villous lymphocytes （SLVL） or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL ...
关键词：splenic lymphoma with villous lymphocytes splenic marginal zone lymphoma transformation chromosometranslocation 
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