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Transcriptional pausing induced by ionizing radiation enables the acquisition of radioresistance in nasopharyngeal carcinoma
《Journal of Molecular Cell Biology》2023年第7期15-30,共16页Honglu Liu Huanyi Fu Chunhong Yu Na Zhang Canhua Huang Lu Lv Chunhong Hu Fang Chen Zhiqiang Xiao Zhuohua Zhang Huasong Lu Kai Yuan 
This project has been supported by grants from the National Natural ScienceFoundation of China(32170821 and 92153301 to K.Y.and 32101034 to F.C.);the Ministry of Science and Technologyyof the People's Republic of China(2021YFC2701202);Department of Science&Technology of Hunan Province(2021J10054 and 2019SK1012 to K.Y.,2021J41049 to C.Y.,and the Innovative Team Program 2019RS1010);Central South University(the Innovationdriven Team Project 2020CX016);K.Y.is supported by the National Thousand Talents Program for Young Outstanding Scientists.
Lesions on the DNA template can impact transcription via distinct regulatory pathways.Ionizing radiation(IR)as the mainstay modality for many malignancies elicits most of the cytotoxicity by inducing a variety of DNA ...
关键词：RNA polymerase II transcriptional pausing RADIORESISTANCE CDK7 NEK7 nasopharyngeal carcinoma 
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