PAUSING

作品数：11被引量：11H指数：2
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相关期刊：《Journal of Computational Mathematics》《Signal Transduction and Targeted Therapy》《Molecular Plant》《Life Metabolism》更多>>
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A histone tale that enCOMPASSes pausing:new insights into the functional repertoire of H3K4me3
《Signal Transduction and Targeted Therapy》2023年第8期3555-3557,共3页Thomas K.Albert Kornelius Kerl 
This work was supported by grants from the Kinderkrebshilfe Muenster,the Deutsche Krebshilfe,the Deutsche Kinderkrebsstiftung and the Deutsche Forschungsgemeinschaft to K.K.
A recently published study in Nature provides compelling evidence for the involvement of the histone H3K4me3 modification in regulating RNA polymerase II(Pol II)pause-release and elongation.1 The expansion of the func...
关键词：INVOLVEMENT functional insight 
Transcriptional pausing induced by ionizing radiation enables the acquisition of radioresistance in nasopharyngeal carcinoma
《Journal of Molecular Cell Biology》2023年第7期15-30,共16页Honglu Liu Huanyi Fu Chunhong Yu Na Zhang Canhua Huang Lu Lv Chunhong Hu Fang Chen Zhiqiang Xiao Zhuohua Zhang Huasong Lu Kai Yuan 
This project has been supported by grants from the National Natural ScienceFoundation of China(32170821 and 92153301 to K.Y.and 32101034 to F.C.);the Ministry of Science and Technologyyof the People's Republic of China(2021YFC2701202);Department of Science&Technology of Hunan Province(2021J10054 and 2019SK1012 to K.Y.,2021J41049 to C.Y.,and the Innovative Team Program 2019RS1010);Central South University(the Innovationdriven Team Project 2020CX016);K.Y.is supported by the National Thousand Talents Program for Young Outstanding Scientists.
Lesions on the DNA template can impact transcription via distinct regulatory pathways.Ionizing radiation(IR)as the mainstay modality for many malignancies elicits most of the cytotoxicity by inducing a variety of DNA ...
关键词：RNA polymerase II transcriptional pausing RADIORESISTANCE CDK7 NEK7 nasopharyngeal carcinoma 
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration被引量：1
《Protein & Cell》2023年第5期318-336,共19页Dawei Meng Qian Zheng Xue Zhang Xuejiao Piao Li Luo Yichang Jia 
the Tsinghua-Peking Joint Center for Life Sciences,the Thousand-Talent Young Investigator Program,the IDG/McGovern Institute for Brain Research,the National Natural Science Foundation of China(81371361,92049114,31571097,82101495);The Beijing Municipal Science&Technology Commission(Z181100001518001,Z161100000216154);National Key R&D Program(2017YFC0110205);the Institute for Guo Qiang,Tsinghua University。
Emerging evidence suggests that intron-detaining transcripts(IDTs)are a nucleus-detained and polyadenylated mRNA pool for cell to quickly and effectively respond to environmental stimuli and stress.However,the underly...
关键词：SNIP1 RNPS1 SPLICEOSOME detained intron NEURODEGENERATION 
H3K4me2/3 modulate the stability of RNA polymerase II pausing
《Cell Research》2023年第5期403-406,共4页Shibin Hu Aixia Song Linna Peng Nan Tang Zhibin Qiao Zhenning Wang Fei Lan Fei Xavier Chen 
grants from the National Key R&D Program of China(2021YFA1301700,2021YFA1300100);the National Natural Science Foundation of China(32070636,32270588);the Shanghai Natural Science Foundation(20ZR1412100,22ZR1412400).
Dear Editor,Modifications of histones are intricately linked with the regulation of gene expression,having demonstrated roles in various physiological processes and pathogenesis.Methylation of histone H3 lysine 4(H3K4...
关键词：instead initiating attributed 
How to make the end of a gene,the simple way
《BIOCELL》2022年第6期1453-1457,共5页KAREL H.M.VAN WELY 
The author is financed in part by the Spanish Government(Ministerio de Ciencia e Innovación,Grant MCIN/AEI PID2019-110574RB-I00).
Transcription termination of nearly all protein-coding genes in mammals requires 3’end processing by a multiprotein complex that will cleave and polyadenylate the messenger RNA precursor.Because a variety of enzyme c...
关键词：RNA transcription RNA polymerase II pausing SPLICING TERMINATION POLYADENYLATION 
DDB1 prepares brown adipocytes for cold-induced thermogenesis
《Life Metabolism》2022年第1期39-53,共15页Xu Wang Shen-Ying Liu Guo-Sheng Hu Hao-Yan Wang Guo-Liang Zhang Xiang Cen Si-Ting Xiang Wen Liu Peng Li Haobin Ye Tong-Jin Zhao 
This work was supported by the National Key R&D Program of China(2020YFA0803601);the National Natural Science Foundation of China(32125022 and 32101046);the China Postdoctoral Science Foundation(2019M661348 and 2020T130115).
Brown adipose tissue(BAT)plays a key role in thermogenesis during acute cold exposure.However,it remains unclear how BAT is prepared to rapidly turn on thermogenic genes.Here,we show that damage-specific DNA binding p...
关键词：brown adipose tissue THERMOGENESIS DDB1 RNA polymerase II promoter-proximal pausing UCP1 PGC1α 
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
《四川生理科学杂志》2021年第11期1985-1985,共1页Kevin C Stein 
Ageing is accompanied by a decline in cellular proteostasis,which underlies many age-related protein misfolding diseases1,2.Yet,how ageing impairs proteostasis remains unclear.As nascent polypeptides represent a subst...
关键词：Ageing TRANSLATIONAL kinetics 
mTERF5 Acts as a Transcriptional Pausing Factor to Positively Regulate Transcription of Chloroplast psbEFLJ被引量：8
《Molecular Plant》2019年第9期1259-1277,共19页Shunhua Ding Yi Zhang Zhi Hu Xiahe Huang Bohan Zhang Qingtao Lu Xiaogang Wen Yingchun Wang Congming Lu 
the National Natural Science Foundation of China(reference number 31730102);the State Key Basic Research and Development Plan of China(reference number 2015CB150105);the Key Research Plan of Frontier Sciences of the Chinese Academy of Sciences(reference number QYZDJ-SSW-SMC003);the Strategic Priority Research Program of the Chinese Academy of Sciences(reference number XDB17030100);the National Key Scientific Instrument and Equipment Development Project of China(grant no.2013YQ030595).
RNA polymerase transcriptional pausing represents a major checkpoint in transcription in bacteria and metazoans,but it is unknown whether this phenomenon occurs in plant organelles.Here,we report that transcriptional ...
关键词：mTERF5 TRANSCRIPTIONAL PAUSING TRANSCRIPTION CHLOROPLAST psbEFLJ 
DISCONTINUOUS GALERKIN CALCULATIONS FOR A NONLINEAR PDE MODEL OF DNA TRANSCRIPTION WITH SHORT, TRANSIENT AND FREQUENT PAUSING
《Journal of Computational Mathematics》2014年第6期601-629,共29页Lisa Davis Tomas Gedeon 
A discontinuous Galerkin finite element method is used to approximate solutions to a classical traffic flow PDE. This PDE is used to model the biological process of transcription; the process of transferring genetic i...
关键词：Discontinuous Galerkin finite element method TRANSCRIPTION LWR traffic flowmodel. 
Ribosome profiling reveals sequence-independent post-initiation pausing as a signature of translation被引量：2
《Cell Research》2014年第7期842-851,共10页Yan Hai Xiangwei Gao Botao Liu Ji Wan Xingqian Zhang Shu-Bing Qian 
The journey of a newly synthesized polypeptide starts in the peptidyltransferase center of the ribosome, from where it traverses the exit tunnel. The interior of the ribosome exit tunnel is neither straight nor smooth...
关键词：RIBOSOME translation 
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