LIDAMYCIN

作品数：19被引量：65H指数：6
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相关领域：医药卫生更多>>
相关作者：刘芳陈淑珍商悦甄永苏吴淑英更多>>
相关机构：中国医学科学院北京协和医学院中国医学科学院中国协和医科大学清华大学更多>>
相关期刊：《Science Bulletin》《中国抗生素杂志》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家高技术研究发展计划国家自然科学基金国家重点基础研究发展计划更多>>
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Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma被引量：9
《World Journal of Gastroenterology》2005年第29期4478-4483,共6页Liang Li Yun-Hong Huang Yi Li Feng-Qiang Wang Bo-Yang Shang Yong-Su Zhen 
Supported by the National High Technology Research and Development Program of China, 863 Program, No. 2002AA2Z346D
AIM： Type IV collagenase including MMP-2 and -9 plays an important role in cancer cell invasion and metastasis and is an attractive target for rnAb-directed therapy. The irnrnunoreactivity of rnAb 3G11, a rnAb direct...
关键词：Type IV collagenase Monoclonal antibody Lidarnycin Colon carcinoma 
Antitumor efficacy of lidamycin on hepatoma and active moiety of its molecule被引量：20
《World Journal of Gastroenterology》2005年第26期3980-3984,共5页Yun-HongHuang Bo-YangShang Yong-SuZhen 
Supported by the National High Technology Research and Development Program of China (863 program), No. 2002AA2Z3107
AIM: To study the in vitro and in vivo antitumor effect of lidamycin (LDM) on hepatoma and the active moiety of its molecule.METHODS: MTT assay was used to determine the growth inhibition of human hepatoma BEL-7402 ce...
关键词：LIDAMYCIN HEPATOMA MITOMYCIN 
Tissue distribution and excretion of ^(125)I-lidamycin in mice and rats被引量：1
《World Journal of Gastroenterology》2005年第21期3281-3284,共4页You-PingLiu Quan-ShengLi Yu-RongHuang Chang-XiaoLiu 
Supported by the National High Technology Research and Development Program of China (863 Program), No. 2003AA2Z347D
AIM: To investigate the tissue distribution, urinary and fecal excretions of 125I-lidamycin (125I-C-1027) in mice and its biliary excretion in rats. METHODS:The total radioactivity assay (RA method) and the radioactiv...
关键词：Distribution EXCRETION LIDAMYCIN C-1027 RA method TCA-RA method 
Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication被引量：12
《World Journal of Gastroenterology》2004年第18期2632-2636,共5页Yue-XinLiang WeiZhang Dian-DongLi Hui-TuLiu PingGao Yi-NaSun Rong-GuangShao 
Supported by Grants from the Major State Basic Research Development Program Foundation of China,No.G2000057010 and G 1999053901 and Grants from the National Natural Science Foundation of China,No.30271438 and 30300424 and Grant from the Key Laborator
AIM: Mitotic cell death has been focused on in tumor therapy.However, the precise mechanisms underlying it remain unclear. We have reported previously that enediyne antibiotic lidamycin induces mitotic cell death at l...
关键词：细胞分裂 细胞凋亡 致死原因 BEL-7402细胞 抗生素 中心体 肝细胞癌 肿瘤 
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