PRION

作品数：175被引量：154H指数：5
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Heat shock cognate 71 (HSC71) regulates cellular antiviral response by impairing formation of VISA aggregates被引量：1
《Protein & Cell》2013年第5期373-382,共10页Zhigang Liu Shu-Wen Wu Cao-Qi Lei Qian Zhou Shu Li Hong-Bing Shu Yan-Yi Wang 
supported by grants from the National Natural Science Foundation of China(Grant No.30921001,91029302,31000639 and 31170792);the National Basic Research Program(973 Program)(No.2012CB910201).
In response to viral infection, RIG-I-like RNA helicases detect viral RNA and signal through the mitochondrial adapter protein VISA. VISA activation leads to rapid activation of transcription factors IRF3 and NF-κB, ...
关键词：HSC71 VISA Cellular antiviral response prion-like aggregate 
Immune Responses in Wild-type Mice Against Prion Proteins Induced Using a DNA Prime-Protein Boost Strategy被引量：3
《Biomedical and Environmental Sciences》2011年第5期523-529,共7页HAN YanLing LI Yuan SONG Juan WANG Ying SHI Qi CHEN Cao ZHANG BaoYun GUO Yan LI ChaoPing HAN Jun DONG XiaoPing 
supported by Chinese National Natural Science Foundation Grants 30771914 and 30800975;Institution Technique R&D Grant (2008EG150300);National Basic Research Program of China (973 Program) (2007CB310505);China Mega-Project for Infectious Disease (2009ZX10004‐101, 2008ZX10004‐001, and 2008ZX10004‐002);the SKLID Development Grant (2008SKLID102 and 2008SKLID202)
Objective To break immune tolerance to prion （PrP） proteins using DNA vaccines.Methods Four different human prion DNA vaccine candidates were constructed based on the pcDNA3.1 vector：PrP‐WT expressing wild‐type P...
关键词：PRION DNA vaccine Humoral response T‐cell response Prime‐boosting regime. 
PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress被引量：4
《Science China(Life Sciences)》2008年第7期630-639,共10页AN Run1 ,2,DONG ChenFang 2,LEI YanJun 1,2,HAN Lu 2,LI Ping 2,CHEN JianMing 2,WANG GuiRong 2, SHI Qi 2 ,GAO Chen 2 ,JIANG HuiYing 2 ,ZHOU Wei 2 ,HAN Jun 2 ,CHU YongLie 1 ,DONG XiaoPing 2 1School of Medicine,Xi’an JiaoTong University,Xi’an 710061,China 2State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,YingXin Rd 100,Beijing 100052,China 
the National Science and Technology Task Force Project(Grant No.2006BAD06A13-2);National Basic Research Program(973 Program)of China(Grant No.2007CB310505);National Natural Science Foundation of China(Grant Nos.30571672,30500018 and 30771914)
One of the physiological functions of cellular prion protein(PrP C )is believed to work as a cellular resistance to oxidative stress,in which the octarepeats region within PrP plays an important role.However,the detai...
关键词：PRION protein oxidative stress GLUTATHIONE PEROXIDASE reactive oxygen species cell VIABILITY 
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