Viral infection triggers the innate antiviral response in part through acti- vation of RIG-I, a cytoplasmic sensor of 5'-triphosphorylated and uncapped single- or double-stranded RNA, which are not found among endoge...
The copper-binding, membrane-anchored, cellular prion protein (PrP~) has two constitutive cleavage sites producing distinct N- and C-terminal fragments (N1/C1 and N2/C2). Using RK13 cells expressing either human P...
Transmissible Spongiform Encephalopathies (TSE), commonly referred to as prion diseases, are a group of rare, infectious and fatal neurodegenerative diseases in mammals. All prion diseases are thought to share a com...