NOXA

作品数：70被引量：132H指数：7
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相关作者：张林杰赵志朱海嘉朱丹霞董华洁更多>>
相关机构：江苏省人民医院郑州大学安徽医科大学南京医科大学更多>>
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相关基金：国家自然科学基金安徽省高校省级自然科学研究项目湖南省自然科学基金青海省科技计划项目更多>>
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瑞戈菲尼通过活化ROS/ER stress通路上调Noxa表达诱导食管癌细胞凋亡的实验研究
《湖北医药学院学报》2025年第1期1-8,共8页赵群 张安杰 龚运来 吴婧轶 付力维 赵明慧 李婷婷 余贤军 
湖北省自然科学基金(2022CFB481);武当特色重要研究湖北省重点实验室开放课题项目(WDCM2023007);湖北省高校中青年创新团队(T2022021);大学生创新创业训练计划项目(S202413249007,202410929010)。
目的:探讨瑞戈菲尼(Regorafenib,Reg)通过激活活性氧/内质网应激(ROS/ER stress)通路诱导食管癌细胞凋亡的作用及分子机制。方法:通过CCK-8及克隆形成方法检测Reg对食管癌细胞ECA109和KYSE150增殖能力的影响;通过流式细胞术和Western b...
关键词：瑞戈菲尼 食管癌 凋亡 NOXA ROS/ER stress通路 
五味子乙素调节Noxa/Hsp27/NF-κB信号通路对哮喘大鼠气道炎症和气道重塑的影响
《中国免疫学杂志》2024年第12期2484-2489,共6页雷俊 罗玲艳 乔松 
武汉市医学科研项目(WZ21C57)。
目的:探讨五味子乙素(Sch B)调节Noxa/热休克蛋白27(Hsp27)/核因子-κB(NF-κB)信号通路对哮喘大鼠气道炎症和气道重塑的影响。方法:将SD雄性大鼠随机分为对照组(正常饲养)、哮喘组、Sch B-L组(40 mg/kg)、Sch B-H组(80 mg/kg)、阳性对...
关键词：哮喘 五味子乙素 Noxa/Hsp27/NF-κB 气道炎症 气道重塑 
Visible-light-induced four-component difunctionalization of alkenes to construct phosphorodithioate-containing quinoxalin-2(1H)-ones
《Chinese Chemical Letters》2024年第11期367-371,共5页Xiao-Ming Chen Lianhui Song Jun Pan Fei Zeng Yi Xie Wei Wei Dong Yi 
supported by Natural Science Foundation of Hunan Province(No.2024JJ7198);Science Research Excellent Youth Project of Hunan Provincial Department of Education(No.23B0751);Natural Science Foundation of Shandong Province(No.ZR2021MB065);National Natural Science Foundation of China(No.22101237)。
A facile visible-light-induced 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene(4Cz IPN)catalyzed fourcomponent reaction of alkenes,quinoxalin-2(1H)-ones,P4S10and alcohols has been developed at room temperature.This...
关键词：Visible-light catalysis Four-component reaction PHOSPHORODITHIOATE Quinoxalin-2(1H)-ones 
Sono-photocatalytic amination of quinoxalin-2(1H)-ones with aliphatic amines
《Chinese Chemical Letters》2024年第10期269-272,共4页Wen-Tao Ouyang Jun Jiang Yan-Fang Jiang Ting Li Yuan-Yuan Liu Hong-Tao Ji Li-Juan Ou Wei-Min He 
financial support from the University of South China。
The first example of sono-photocatalytic bond formation was reported.With both visible light and ultrasound wave as the energy,various 3-aminoquinoxalin-2(1H)-ones were efficiently obtained with good functional group ...
关键词：Sono-photocatalysis External photocatalyst-free Quinoxalin-2(1H)-ones Amination Aliphatic amines 
Feasible Synthesis of N,O-Bidentate Difluoroboron Chromophores through Direct Functionalization of Quinoxalin-2(1H)-ones with Ketones in One Shot
《Chinese Journal of Chemistry》2024年第13期1481-1486,共6页Shuaichen Zhang Jing Zhang Xiang Ling Yifan Zhao Yue Ma Peng Sun 
The authors thank the generous financial support from the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2021A05102);the National Natural Science Foundation of China(21702235,82141001);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-YQ-098,ZZ14-FL-010,ZZ15-ND-10).
Organic difluoroboron complexes are a kind of potential platforms for a wide range of applications owing to their excellent photophysical properties.Herein,we have explored a simple and direct synthesis methodology fo...
关键词：N O-Bidentate difluoroboron CHROMOPHORES Quinoxalin-2(1H)-ones Ketones/Green chemistry Synthetic method C-CcouplingI Boron 
Gambogenic acid induces apoptosis via upregulation of Noxa in oral squamous cell carcinoma被引量：1
《Chinese Journal of Natural Medicines》2024年第7期632-642,共11页CHENG Xinran FENG Mengyuan ZHANG Anjie GUO Jian GONG Yunlai HU Xiaohui HAN Quanbin LI Shengbao YU Xianjun 
supported by the Projects of International Cooperation and Exchanges(No.G2022027012L);the Natural Science Foundation of Hubei Provincial Department of Education(No.T2022021);the Advantages Discipline Group(Medicine)Project in Higher Education of Hubei Province(2021-2025)(Nos.2024XKQY26 and 2023BMXKQY2);the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research of Hubei University of Medicine(No.WDCM2023007);the Innovative Research Program for Graduates of Hubei University of Medicine(No.YC2022033,YC2024003).
Gambogenic acid(GNA),a bioactive compound derived from the resin of Garcinia hanburyi,has demonstrated significant antitumor properties.However,its mechanisms of action in oral squamous cell carcinoma(OSCC)remain larg...
关键词：Oral squamous cell carcinoma Gambogenic acid APOPTOSIS NOXA ROS/ER stress 
薯蓣皂苷对口腔鳞癌细胞增殖和凋亡的影响被引量：1
《临床口腔医学杂志》2024年第3期131-135,共5页张慧琳 章作号 龚伶玲 王小聪 乐曼妮 黄子璇 李明 张睿 
湖南省自然科学基金面上基金项目(编号2022JJ30630);湖南省教育厅重点项目(编号22A0249);长沙市自然科学基金项目(编号kq2208458);湖南省科技厅临床医疗技术创新引导项目(编号2021SK53301);湖南省卫生健康委员会重点指导课题(编号202108051626)。
目的:探讨薯蓣皂苷对人口腔鳞癌细胞SCC-4和SCC-25增殖和凋亡的影响。方法:不同浓度(0、0.1、0.3、1、3、10、30μmol/L)薯蓣皂苷处理SCC-4和SCC-25细胞24、48、72 h后,CCK-8法检测薯蓣皂苷对SCC-4和SCC-25细胞存活的影响,根据IC_(50)...
关键词：薯蓣皂苷 口腔鳞状细胞癌 凋亡 NOXA 
Visible-light-promoted tandem decarboxylation coupling/cyclization of N-aryl glycines with quinoxalinones: Easy access to tetrahydroimidazo [1,5-a]quinoxalin-4(5H)-ones
《Green Synthesis and Catalysis》2024年第1期31-34,共4页Zhen Tang Chao Pi Yangjie Wu Xiuling Cui 
We acknowledge partial financial support from the Ministry of Science and Technology of China(No.2016YFE0132600);Henan Center for Outstanding Overseas Scientists(No.GZS2020001)and Zhengzhou University。
A visible-light-promoted formal[2+2+1]cyclization of N-aryl glycines with quinoxalin-2(1H)-ones to synthesize tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones have been developed.The protocol features operational simplic...
关键词：CYCLIZATION DECARBOXYLATION Visible-light-promoted Quinoxalin-2(1H)-ones Mild conditions 
Visible-light-enabled multicomponent synthesis of trifluoromethylated 3-indolequinoxalin-2(1H)-ones without external photocatalysis
《Green Synthesis and Catalysis》2024年第1期51-56,共6页Letian Zhang Kai Zheng Pengfei Zhang Min Jiang Jiabin Shen Chao Chen Chao Shen 
This work was supported by Basic Scientific Research Special Funds(No.2020XZ011);Zhejiang Shuren University,the"Ten-thousand Talents Plan"of Zhejiang Province(No.2019R51012);the Technology Research and Development Program of Hangzhou(No.20191203B28);the National Natural Science Foundation of China(No.21302171).
A novel and sustainable visible-light-enabled multicomponent reaction involving quinoxalin-2(1H)-ones,indoles,and CF3SO2Na that does not require an external photocatalyst is described.This photoinduced reaction employ...
关键词：Visible-light-catalysis Three-component reaction TRIFLUOROMETHYLATION Quinoxalin-2(1H)-Ones INDOLES 
α-常春藤皂苷通过激活和稳定p53/Noxa信号诱导肝癌细胞凋亡
《医药导报》2024年第3期334-345,共12页陈晓静 周莉 刘凯琪 段菊凤 刘明 李洪亮 汪选斌 
国家自然科学基金面上项目(82274155);湖北省科技厅对外合作项目(2022EHB046);湖北省科技厅自然基金面上项目(2023AFB925);武当特色中药研究湖北省重点实验室开放课题(WDCM2018002,WDCM201917,WDCM201918);“十四五”湖北省高等学校优势特色学科群(现代医学)项目(2022XKQY3)。
目的研究预知子活性成分α-常春藤皂苷对肝癌细胞的体内外抑制作用及其机制。方法将肝癌细胞分为4组,分别给予0、10、20和30μmol·L^(-1)α-常春藤皂苷至24、48 h。噻唑蓝(MTT)法检测细胞增殖,流式细胞术检测凋亡率,转录组学筛选α-常...
关键词：α-常春藤皂苷 肝细胞癌 凋亡 P53 NOXA 
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