POLYLYSINE

作品数：18被引量：28H指数：3
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相关领域：医药卫生更多>>
相关作者：龚英陈克敏钟高仁汪登斌更多>>
相关机构：上海交通大学医学院附属瑞金医院更多>>
相关期刊：《Science China(Life Sciences)》《Engineered Regeneration》《Bioactive Materials》《Chemical Research in Chinese Universities》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金更多>>
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Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy被引量：6
《Science China(Life Sciences)》2018年第4期436-447,共12页Jiajia Xiang Bihan Wu Zhuxian Zhou Shiqi Hu Ying Piao Quan Zhou Guowei Wang Jianbin Tang Xiangrui Liu Youqing Shen 
supported by the National Natural Science Foundation of China (U1501243, 51603181);the National Basic Research Program (2014CB931900);the National Natural Science Foundation of China (51603181);the Fundamental Research Funds for the Central Universities (2016QNA4024) for financial support
Paclitaxel(PTX) is one of the most effective anticancer drugs for the treatment of various solid tumors, but its clinical use is limited by its poor solubility, low bioavailability, and severe systemic toxicity. Encap...
关键词：paclitaxel delivery paclitaxel-binding phenethyl isothiocyanate dendritic polylysine polymeric micelles cancer drugdelivery enhanced stability prolonged blood circulation 
Effects of Chirality on Gene Delivery Efficiency of Polylysine被引量：3
《Chinese Journal of Polymer Science》2016年第1期94-103,共10页Bin-wei Zhao Zhuxian Zhou 申有青 
financially supported by the National Basic Research Program(No.2014CB931900);the National Natural Science Foundation of China(No.21090352)
Chirality is a key factor in the biological activity of many biomolecules. Poly（L-lysine）（PLL）, a polypeptide synthesized from L-lysine, is one of the mostly used cationic polymers for gene delivery. The effect of...
关键词：Gene delivery Gene transfection Chiral effects Polylysine 
Polylysine-modified Polyethylenimines as siRNA Carriers for Effective Tumor Treatment被引量：2
《Chinese Journal of Polymer Science》2015年第6期830-837,共8页Jie Chen Zi-xue Jiao Lin Lin Zhao-pei Guo Cai-na Xu Yan-hui Li 田华雨 Xue-si Chen 
financially supported by the National Natural Science Foundation of China(Nos.51222307,51303173,51390480,21474104 and 51403205);the Ministry of Science and Technology of China(International cooperation and communication program 2011DFR51090);Jilin Province Science and Technology Development Program(Nos.20120306,20130521011JH)
Polyethylenimine-poly（L-lysine） （PEI-PLL） copolymer was synthesized via ring-opening polymerization of L-lysine N-carboxyanhydride （Lys（Z）-NCA） initiated by PEI. The complexation of PEI-PLL with siRNA was stud...
关键词：Gene carrier Gene silencing POLYLYSINE Tumor treatment VEGF siRNA. 
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