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作品数：3被引量：70H指数：2
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相关期刊：《Open Journal of Medicinal Chemistry》《World Journal of Gastroenterology》更多>>
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Novel Cytocidal Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl) Benzenesulfonates and Benzenesulfonamides with Affinity to the Colchicine-Binding Site: Is the Phenyl 2-Imidazolidinone Moiety a New Haptophore for the Design of New Antimitotics?
《Open Journal of Medicinal Chemistry》2015年第1期9-22,共14页Sébastien Fortin Lianhu Wei Lakshmi P. Kotra René C.-Gaudreault 
Phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB-SOs) and phenyl 4-(2-oxoimidazolidin- 1-yl)benzenesulfonamides (PIB-SAs) are new, potent combretastatin A-4 (CA-4) analogs designed on the basis of their common ...
关键词：Docking Colchicine-Binding Site Ligands Antimicrotubule Agents PIB-SO PIB-SA 
JTE-522-induced apoptosis in human gastric adenocarinoma cell line AGS cells by caspase activation accompanying cytochrome C release,membrane translocation of Bax and loss of mitochondrial membrane potential被引量：16
《World Journal of Gastroenterology》2002年第2期217-223,共7页Hong-Liang Li Xiao-Hong Li Jun-Hua Lü Xian-Da Ren,Department of Pharmacology,Jinan University Pharmacy College,Guangzhou 510632,Guangdong Province,China Dan-Dan Chen,Department of Cardiology,First Affiliated Hospital,Zhongshan University,Guangzhou 510089,Guangdong Province,China Hai-Wei Zhang,Department of Pathology,Jinan University Medical College,Guangzhou 510632,Guangdong Province,China Cun-Chuan Wang,Department of laparoscopic surgery,First Affiliated Hospital,Jinan University Medical College,Guangzhou 510632,Guangdong Province,China 
National Natural Science Foundation of China,No.39770300,30070873;the Overseas Chinese Affairs Office of the State Council Foundation,No.98-33
AIM: To investigate the role of the mitochondrial pathway in JTE-522-induced apoptosis and to investigate the relationship between cytochrome C release, caspase activity and loss of mitochondrial membrane potential (D...
关键词：Adenocarcinoma Stomach Neoplasms Amino Acid Chloromethyl Ketones Anti-Inflammatory Agents  Non-Steroidal Apoptosis BENZENESULFONATES CASPASES inhibitors Cyclooxygenase Inhibitors Cysteine Proteinase Inhibitors Cytochrome c Group Enzyme Activation Humans In Situ Nick-End Labeling Membrane Potentials Mitochondria OXAZOLES Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Research Support  Non-U.S. Gov't Tumor Cells  Cultured bcl-2-Associated X Protein 
Changes of NF-kB,p53,Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells:role of reactive oxygen species被引量：58
《World Journal of Gastroenterology》2002年第3期431-435,共5页Hong-Liang Li Xiao-Hong Li Yan-Qing L Chun-Ling Ye Xian-Da Ren,Department of Pharmacology,Jinan University Pharmacy College,Guangzhou 510632,Guangdong,China Dan-Dan Chen,Department of Cardiology,First Affiliated Hospital,Zhongshan University,Guangzhou 510089,Guangdong,China Hai-Wei Zhang,Department of Pathology,Jinan University Medical College,Guangzhou 510632,Guangdong,China 
National Natural Science Foundation of China,No.39770300,30070873;the Overseas Chinese Affairs Office of the State Council Foundation,No.98-33
AIM: To identify whether JTE-522 can induce apoptosis in AGS cells and ROS also involved in the process, and to investigate the changes in NF-kB, p53, bcl-2 and caspase in the apoptosis process. METHODS: Cell culture,...
关键词：I-kappa B Proteins Adenocarcinoma APOPTOSIS BENZENESULFONATES CASPASES Cell Division DNA-Binding Proteins Humans NF-kappa B OXAZOLES Proto-Oncogene Proteins c-bcl-2 Reactive Oxygen Species Research Support  Non-U.S. Gov't Stomach Neoplasms Tumor Cells  Cultured Tumor Suppressor Protein p53 
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