ANALGESICS

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Highly Oxygenated Dimeric Grayanane Diterpenoids as Analgesics:TRPV1 and TRPA1 Dual Antagonists from Rhododendron molle被引量：3
《Chinese Journal of Chemistry》2022年第19期2285-2295,共11页Lang Huang Guijuan Zheng Yuanyuan Feng Pengfei Jin Biao Gao Hanqi Zhang Xiaomin Ma Junfei Zhou Guangmin Yao 
This work was supported by the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2022-KF08);the Fund of Laboratory of Xinjiang Native Medicinal and Edible Plant Resource Chemistry(KSUZDSYS202101);the National Natural Science Foundation of China(22107033 and U1703109);the Traditional Chinese Medicine of Hubei Provincial Health Commission(ZY2021M056);the China Postdoctoral Science Foundation(2021M691152)。
Six highly oxygenated dimeric grayanane diterpenoids(1—6)including three new ones,bismollethers A—C(1—3),were isolated from the flowers of Rhododendron molle collected at Qichun,Hubei,China.The structures and relat...
关键词：Biological activity Dimeric grayanane diterpenoids Natural products Rhododendron molle(Ericaceae) Structure elucidation 
Discovery of Kalmane Diterpenoids as Potent Analgesics from the Flowers of Rhododendron dauricum被引量：2
《Chinese Journal of Chemistry》2022年第9期1019-1027,共9页Yuanyuan Feng Suqin Zha Biao Gao Hanqi Zhang Pengfei Jin Guijuan Zheng Yilin Ma Guangmin Yao 
This work was financially supported by the Scientific Research Project of Traditional Chinese Medicine of Hubei Provincial Health Commission(ZY2021M056);the Open Project of State Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources(No.CMEMR-2021-B03)。
Kalmane diterpenoids,featuring a 5/8/5/5 tetracyclic carbon skeleton,are very rare in nature.The flowers of Rhododendron dauricum L.(Ericaceae)were phytochemically investigated for the first time,leading to the isolat...
关键词：Biological activity Kalmane diterpenoids Natural products Rhododendron dauricum L.(Ericaceae) Structure elucidation 
Epoxymicranthols A-N,5,9-Epoxygrayanane Diterpenoids as Potent Analgesics from Rhododendron micranthum被引量：2
《Chinese Journal of Chemistry》2021年第7期1997-2008,共12页Pengfei Jin Xinghua Yuan Xiaomin Ma Guijuan Zheng Ru Wang Na Sun Guangmin Yao 
This work was financially supported by the National Natural Science Foundation of China(No.U1703109).
Main observation and conclusion Fifteen 5,9-epoxygrayanane diterpenoids(1-15)including fourteen new ones,epoxymicranthols A-N(1-14),were isolated from the leaves extract of Rhododendron micranthum.Their structures wer...
关键词：Rhododendron micranthum Turcz.(Ericaceae) Natural products Structural elucidation ANALGESICS Structure-activity relationship 
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