Alpha-fetoprotein(AFP)-producing adenocarcinoma,histologically mimicking hepatocellular carcinoma(HCC),is a distinct entity known as hepatoid adenocarcinoma(HAC).Reported cases of HAC arising from the esophagus are ex...
Objectives:To investigate the impact of serumα-fetoprotein(AFP)levels on survival and early recurrence after R0 resection in primary hepatocellular carcinoma(HCC).Methods:We retrospectively analyzed clinical data of ...
Background The second-trimester maternal serum screening in twin pregnancy is still controversial, as the serum marker levels in twins are not as clear as those in singletons. This study aimed to evaluate the relation...
This work was supported by National NaturalScience Fundation of China(No.39760077).
AIM: The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS: The effect of AFP on the...
The prognosis of patients with HCC still remains dismal. The life expectancy of HCC patients is hard to predict because of the high possibility of postoperative recurrence. Many factors, such as patient's general cond...
National Natural Science Foundation of China,No.39760077
AIM: The goal of this study was to characterize the AFP receptor, its possible signal transduction pathway and its proliferative functions in human hepatoma cell line Bel 7402. METHODS: Cell proliferation enhanced by ...
Supportod ty the State Key Basic Research Program Grant G1998051211 the Fund for Leading Specialty of Shanghai Metropolitan Bureau of Public Health.
AIM: To establish clone cells with different metastatic potential for the study of metastasis-related mechanisms. METHODS: Cloning procedure was performed on parental hepatocellular carcinoma (HCC) cell line MHCC97, a...
Supported by the National Postdoctoral Science Foundation of China,No.199711.
AIM: To evaluate antihepatoma effect of antisense phosphorothioate oligodeoxyribonucleotides (S-ODNs) targeted to alpha-fetoprotein (AFP) genes in vitro and in nude mice. METHODS: AFP gene expression was examined by i...
Supported by the grant from the Guangxi Science;Technology Committee, No. 9811003
INTRODUCTIONThe increased expression of ICAM-1 on a widerange of cells and in the sera of patients withmalignancies, chronic liver diseases andinflammation diseases has been described since thelate 1980s[1-22]. Recent...
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