the grants from the National Natural Science Foundation of China (81402776 and 81202400);the Key National S&T Progra m "Major New Drug Development" of the Ministry of Science and Technology of China (2012ZX09504001-003);the Fundamental Research Funds for the Central Universities (lzujbky-2014-142 and lzujbky-2015-169);the Specialized Research Fund for the Doctoral Program of Higher Education of China (20130211130005);China Postdoctoral Science Foundation (2013T60896)
The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Ac r_3-NLS, by conjuga...