ACRIDINES

作品数:3被引量:1H指数:1
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相关机构:中国科学技术大学更多>>
相关期刊:《Chinese Medical Journal》《Engineering》《Chinese Chemical Letters》更多>>
相关基金:国家自然科学基金中国博士后科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide
《Engineering》2015年第4期500-505,共6页Wei Zhang Xiaoli Yang Jingjing Song Xin Zheng Jianbo Chen Panpan Ma Bangzhi Zhang Rui Wang 
the grants from the National Natural Science Foundation of China (81402776 and 81202400);the Key National S&T Progra m "Major New Drug Development" of the Ministry of Science and Technology of China (2012ZX09504001-003);the Fundamental Research Funds for the Central Universities (lzujbky-2014-142 and lzujbky-2015-169);the Specialized Research Fund for the Doctoral Program of Higher Education of China (20130211130005);China Postdoctoral Science Foundation (2013T60896)
The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Ac r_3-NLS, by conjuga...
关键词:ACRIDINE nuclear localization sequence CONJUGATE antimicrobial activity mechanism of action 
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