ACRIDINES

作品数：3被引量：1H指数：1
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相关机构：中国科学技术大学更多>>
相关期刊：《Chinese Medical Journal》《Engineering》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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Design,synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP and Topo inhibitors for potential anticancer agents
《Chinese Chemical Letters》2020年第2期404-408,共5页Qiuzi Dai Jiwei Chen Chunmei Gao Qinsheng Sun Zigao Yuan Yuyang Jiang 
financial supports from the Shenzhen Development and Reform Committee(Nos.20151961 and 2019156);Department of Science and Technology of Guangdong Province(No.2017B030314083)。
In this study,we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors.MTT assays indicated that most of the compounds significantly inhibited multiple cancer cells p...
关键词：TOPO PARP Multitarget ACRIDINES ANTITUMOR bioactivity 
Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide
《Engineering》2015年第4期500-505,共6页Wei Zhang Xiaoli Yang Jingjing Song Xin Zheng Jianbo Chen Panpan Ma Bangzhi Zhang Rui Wang 
the grants from the National Natural Science Foundation of China (81402776 and 81202400);the Key National S&T Progra m "Major New Drug Development" of the Ministry of Science and Technology of China (2012ZX09504001-003);the Fundamental Research Funds for the Central Universities (lzujbky-2014-142 and lzujbky-2015-169);the Specialized Research Fund for the Doctoral Program of Higher Education of China (20130211130005);China Postdoctoral Science Foundation (2013T60896)
The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Ac r_3-NLS, by conjuga...
关键词：ACRIDINE nuclear localization sequence CONJUGATE antimicrobial activity mechanism of action 
Combination and cleavage of HBV DNA fragments by triple helix-forming oligonucleotides modified with manganese porphyrin in vitro被引量：1
《Chinese Medical Journal》2003年第8期1248-1252,共5页光丽霞 袁发焕 奚敏 赵聪敏 刘立 温恩懿 艾友萍 
ThisstudywassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina (No 3 980 0 12 8)
Objective To observe the ability of triple helix-forming oligonucleotides (TFOs) modified with manganese porphyrin to combine with and cleave HBV DNA fractions. Methods TFO were modified with manganese porphyrin and...
关键词：oligodeoxyribonucleotides·hepatitis B virus·manganese·porphyrins·acridines 
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