DEAMIDATION

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相关机构：中国农业大学更多>>
相关期刊：《Science China(Life Sciences)》《Frontiers of Chemical Science and Engineering》《Journal of Analysis and Testing》更多>>
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Elucidating the Degradation Pathways of Human Insulin in the Solid State
《Journal of Analysis and Testing》2024年第3期288-299,共12页Andrew Fagan Lorraine M.Bateman Joseph P.O’Shea Abina M.Crean 
supported in part by a research grant from Science Foundation Ireland(SFI)and is co-funded under the European Regional Development Fund(grant numbers 12/RC/2275(P2)and 18/EPSRC-CDT/3587);the Engineering and Physical Sciences Research Council UK(grant number EP/S023054/1).
While there have been significant advances in the development of peptide oral dosage forms in recent years,highlighted by the clinical and commercial success of approved peptides such as Rybelsus®,there remain several...
关键词：INSULIN Stability Solid state DEAMIDATION Covalent aggregation Disulfide cleavage Biopharmaceutical analysis 
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway
《Science China(Life Sciences)》2024年第9期1915-1927,共13页Ling Li Lei Lu Ziqi Xiao Jingyi Lv Hefeng Huang Bo Wu Tongjin Zhao Chengtao Li Weimin Wang Hongyan Wang 
supported by the National Key Research and Development Program of China(2021YFC2701101);the National Natural Science Foundation of China(82150008,81930036);Commission for Science and Technology of Shanghai Municipality(20JC1418500);Open Fund Project of Guangdong Academy of Medical Sciences(YKY-KF202202)。
The BMP signaling pathway plays a crucial role in regulating early embryonic development and tissue homeostasis.SMAD6 encodes a negative regulator of BMP,and rare variants of SMAD6 are recurrently found in individuals...
关键词：SMAD6 DEAMIDATION BMP signaling pathway GFPT2 
Effect of succinic acid deamidation-induced modification on wheat gluten
《Frontiers of Chemical Science and Engineering》2009年第4期386-392,共7页Lan LIAO Mouming ZHAO Haifeng ZHAO Jiaoyan REN Chun CUI Xiao HU 
the National High Technology Research and Development Program of China(Grant No.2006AA10Z326);the National Natural Science Foundation of China(Grant No.20676044)for their financial support.
The effect of succinic acid deamidationinduced modification on wheat gluten was investigated in the present study.The changes of surface hydrophobicity,functional properties,secondary structure,and sensibility of prot...
关键词：wheat gluten DEAMIDATION succinic acid functional properties protein conformation sensibility of proteolysis 
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