supported by the National Natural Science Foundation of China(82370631);the Talent Foundations from Army Medical University(4174C6),the Chongqing Government(CQYC20220303727)to Xie CM;the National Natural Science Foundation of China(31900449)to Xiong HJ.
Background:Kirsten rat sarcoma(KRAS)and mutant KRAS^(G12D)have been implicated in human cancers,but it remains unclear whether their activation requires ubiquitination.This study aimed to investigate whether and how F...
funded by a USDA-ARS grant in the form of a Non-Assistance Cooperative Agreement#58-6054-0-010;approved for publication by the Louisiana Agricultural Experiment Station as MS#2024-306-39132.
Maize(Zea mays),a major food crop worldwide,is susceptible to infection by the saprophytic fungus Aspergillus flavus that can produce the carcinogenic metabolite aflatoxin(AF)especially under climate change induced ab...
目的·研究F-box蛋白38(F-box only protein 38,FBXO38)对眼部黑色素瘤增殖的作用以及潜在的调控通路。方法·使用FBXO38短发夹RNA(short hairpin RNA,shRNA)和FBXO38过表达质粒构建FBXO38敲低以及过表达的人皮肤黑色素瘤A375和葡萄膜...
supported by the National Institutes of Health National Institute of General Medical Sciences[Grant R35GM118041];supported in part by the National Cancer Institute of the National Institutes of Health under Award Number P30 CA021765。
Pregnane X receptor(PXR)is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes[e.g.,cytochrome P4503A4(CYP3A4)]and transporters.Although the regulation of PXR target genes ...