TROPANE

作品数：5被引量：46H指数：2
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相关作者：刘晶莹更多>>
相关机构：北京师范大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Science China Chemistry》《Science Bulletin》《Journal of Shanghai Jiaotong university(Science)》更多>>
相关基金：国家自然科学基金更多>>
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Highly stereoselective construction of polycyclic benzofused tropane scaffolds and their latent bioactivities: bifunctional phosphonium salt-enabled cyclodearomatization process被引量：1
《Science China Chemistry》2020年第8期1091-1099,共9页Jian-Ping Tan Xiaojie Li Yuan Chen Xianle Rong Lixiang Zhu Chunhui Jiang Kai Xiao Tianli Wang 
supported by the National Natural Science Foundation of China(21971165,21921002,81630101);the National Key Research and Development Program of China(2018YFA0903500);the“1000-Youth Talents Program”(YJ201702);the Fundamental Research Funds for the Central Universities。
Structurally fused heterocycles encompassing a centerpiece of benzotropane are significant scaffolds with a plethora of promising biological activities,but such molecular architectures pose a long-standing daunting sy...
关键词：bifunctional phosphonium salts benzofused tropanes cyclic azomethine ylides cyclodearomatization antitumor activity 
Stereoselectivity of satropane, a novel tropane analog, on iris muscarinic receptor activation and intraocular hypotension被引量：3
《Acta Pharmacologica Sinica》2008年第2期177-184,共8页Liang ZHU Li-min YANG Yong-yao CUI Pei-li ZHENG Yin-yao NIU Hao WANG Yang LU Qiu-shi REN Pi-jing WEI Hong-zhuan CHEN 
Project supported by the National Natural Science Foundation of China （No 30472012）, the Major State Basic Research Development Program of China （No 2005CB724302）, and the Key Project of Shanghai Municipal Science and Technology Commission （No 034319230 and 03JC14064）.
Aim： To study the stereoselectivity of satropane （3-paramethylbenzene sulfonyloxy- 6-acetoxy tropane）, a novel tropane analog, on iris muscarinic receptor activation and intraocular hypotension. Methods： The assay...
关键词：muscarinic receptor chiral tropane analog satropane lesatropane 
Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures
《Journal of Shanghai Jiaotong university(Science)》2004年第4期10-10,共1页
Scopolamine is a pharmaceutically important tropane alkaloid extensively used as an anticholinergic agent.Here,we report the simultaneous introduction and overexpression of genes encoding the rate-limiting upstream en...
Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures被引量：42
《第二军医大学学报》2004年第6期589-589,共1页ZHANGLei DINGRu-Xian CHAIYou-Rong MercedesBonfill ElisabeMoyano Kirsi-MarjaOksman-Caldentey XUTie-Feng PIYan WANGZi-Nan ZHANGHan-Ming KAIGuo-Yin LIAOZhi-Hua SUNXiao-Fen TANGKe-Xuan 
Scopolamine is a pharmaceutically important tropane alkaloid extensively used as an anticholinergic agent.Here,we report the simultaneous introduction and overexpression of genes encoding the rate-limiting upstream en...
关键词：东莨菪碱 生物碱 遗传因子 生物反应器 
NMR Studies on the Configuration of 6-Chloro Nitrile Epimers of Tropane Derivatives
《Chinese Science Bulletin》1993年第6期491-495,共5页杨宪斌 裴学锋 江忝益 沈家祥 
Baogongteng A is a tropane alkaloid with cholinergic activity. It has been used clinically for the treatment of glaucoma, and its pharmacological activity on heart function has also been reported.In the synthesis of b...
关键词：NMR spectroscopy EPIMER TROPANE derivative. 
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