KETOREDUCTASE

作品数：3被引量：1H指数：1
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相关领域：医药卫生化学工程更多>>
相关作者：贾光更多>>
相关机构：东北农业大学北京大学更多>>
相关期刊：《Chinese Journal of Chemistry》《Science China(Life Sciences)》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金更多>>
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Asymmetric synthesis of syn-aryl-(2S,3R)-2-chloro-3-hydroxy esters via an engineered ketoreductase-catalyzed dynamic reductive kinetic resolution
《Chinese Chemical Letters》2023年第9期156-159,共4页Xiaoping Yue Yitong Li Di Sang Yuan Tao Zedu Huang Fener Chen 
The National Key Research and Development Program of China(Nos.2021YFA0911400 and 2021YFF0600704);the National Natural Science Foundation of China(Nos.22071033 and 21801047)are acknowledged for the financial supports。
We report here a generic,green synthesis of 17 valuable syn-aryl-(2S,3R)-2–chloro-3–hydroxy esters(syn-(2S,3R)-1)in 73%-99%isolated yields along with 6.1:1–83:1 dr and 31%~>99%ee,through dynamic reductive kinetic r...
关键词：(2S 3R)-2-Chloro-3-hydroxy esters Dynamic reductive kinetic resolution KETOREDUCTASE Directed evolution Asymmetric synthesis 
Facile Access to Chiral Alcohols with Pharmaceutical Relevance Using a Ketoreductase Newly Mined from Pichia guilliermondi
《Chinese Journal of Chemistry》2013年第3期349-354,共6页Guochao Xu Huilei Yu Jianhe Xu 
This work was financially supported by the National Natural Science Foundation of China （No 21276082）, Ministry of Science and Technology, P. R. China （No.2011CB710800）, China National Special Fund for State Key Laboratory of Bioreactor Engineering （No. 2060204）.
Chiral secondary alcohols with additional functional groups are frequently required as important and valuable synthons for pharmaceuticals, agricultural and other fine chemicals. With the advantages of environmentally...
关键词：carbonyl reductase asymmetric reduction chiral alcohols Pichia guilliermondii BIOCATALYSIS 
A ketoreductase gene from Streptomyces mycarofaciens 1748 DNA involved in biosynthesis of a spore pigment被引量：1
《Science China(Life Sciences)》1997年第6期636-641,共6页夏焕章 王以光 
Project supported by the National Natural Science Foundation of China.
An efficient plasmid transformation system for S. mycarofaciens 1748 has been established. In order to determine the function of MKR gene in S. mycarofaciens 1748, the gene disruption experiment was carried out. For t...
关键词：GENE disruption SPORE PIGMENT KETOREDUCTASE midecamycin. 
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