NIGERICIN

作品数：6被引量：43H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：徐锋王凤王学曾南补娟更多>>
相关机构：成都中医药大学新疆维吾尔自治区人民医院新疆维吾尔自治区疾病预防控制中心更多>>
相关期刊：《Frontiers of Medicine》《World Journal of Gastroenterology》《山东医药》《中药材》更多>>
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Author correction to‘Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics’[Acta Pharm Sin B 12(2022)4458–4471]
《Acta Pharmaceutica Sinica B》2024年第5期2359-2360,共2页Qiang Niu Yu Liu Yujing Zheng Ziwei Tang Yuna Qian Ruogu Qi Jianliang Shen Ping Zhao 
The authors regret that there is an error in Fig.6 in the article due to the mistake of copying and pasting in the process of assemblingfigures and negligence in the proofreading.Although it does not affect the conclus...
关键词：journal CORRECTION conclusion 
Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics被引量：5
《Acta Pharmaceutica Sinica B》2022年第12期4458-4471,共14页Qiang Niu Yu Liu Yujing Zheng Ziwei Tang Yuna Qian Ruogu Qi Jianliang Shen Ping Zhao 
This work was financially supported by the National Nature Science Foundation of China(No.21671150,52073145,21877084);the Key Research Projects of Guangdong Province(NO.2021ZDZX4019).
Pyroptosis provides a new window for relieving the tumor immunosuppressive microenvironment(TIM)and promoting systemic immune responses for tumor treatments.However,gasdermin D(GSDMD),a key protein in the pyroptosis p...
关键词：Self-assembled nanoparticle PYROPTOSIS NLRP3 GSDMD Inflammation IL-8 Immunotherapy responses Solid tumor 
刺槐素对Nigericin诱导小鼠骨髓巨噬细胞NLRP3炎症小体活化的影响被引量：3
《山东医药》2022年第7期10-13,49,共5页补娟 史深 周玲 张晓玲 叶勒丹·马汉 朱沂 
新疆维吾尔自治区卫生健康青年医学科技人才专项(WJWY-202002);新疆维吾尔自治区自然科学基金资助项目(2020D01C095)。
目的探讨刺槐素对尼日利亚菌素(Nigericin)诱导的小鼠骨髓巨噬细胞(BMDM)含NLR家族Pyrin域蛋白3(NLRP3)炎症小体活化的影响。方法分离并培养小鼠BMDM细胞,将BMDM细胞随机分为空白对照组、LPS组、LPS+Nigericin组、LPS+2.5μmol/L刺槐素+...
关键词：刺槐素 含NLR家族Pyrin域蛋白3炎症小体 尼日利亚菌素 巨噬细胞 小鼠 
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity被引量：17
《Frontiers of Medicine》2021年第4期594-607,共14页Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai 
This work has been supported by the Beijing Nova Program(No.Z181100006218001);the National Natural Science Foundation of China(Nos.81874368,81630100,81903891,and 81573676);the National Science and Technology Major Project “Key New Drug Creation and Manufacturing Program”(Nos.2017ZX09301022 and 2018ZX09101002-001-002);the Innovation Groups of the National Natural Science Foundation of China(No.81721002).
Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations ...
关键词：Psoraleae Fructus bavachin idiosyncratic drug-induced liver injury CASPASE-1 IL-lp NLRP3 inflammasome 
基于THP-1细胞模型荆芥挥发油抗炎作用的NLRP3炎症小体调控机制研究被引量：12
《中药材》2017年第3期689-694,共6页王凤 徐锋 温桃群 桑文涛 周洪莉 王学 曾南 
国家自然科学基金(81473399);四川省科技厅资助项目(2014TD0007);国家基础科学人才培养基金项目(J1310034-09)
目的:以THP-1细胞为载体,观察荆芥挥发油抗炎作用及与NLRP3炎症小体激活相关的调控作用机制。方法:MTS法测定荆芥挥发油对THP-1细胞的毒性作用;利用佛波酯(PMA)将THP-1细胞诱导分化为巨噬细胞,然后采用LPS与激活物(ATP、Nigericin、CPPD...
关键词：荆芥挥发油 THP-1细胞 NIGERICIN ATP NLRP3炎症小体 
Suppression of colorectal cancer metastasis by nigericin through inhibition of epithelial-mesenchymal transition被引量：6
《World Journal of Gastroenterology》2012年第21期2640-2648,共9页Hou-Min Zhou Tao-Tao Dong Lin-Lin Wang Bo Feng Hong-Chao Zhao Xiu-Ke Fan Min-Hua Zheng 
Supported by The National Natural Science Foundation, No.30901424;the Leading Medical Talent Foundation of Shanghai Municipality, No. 10XD1402700
AIM: To evaluate the effect of nigericin on colorectal cancer and to explore its possible mechanism. METHODS: The human colorectal cancer (CRC) cell lines HT29 and SW480 were treated with nigericin or oxaliplatin unde...
关键词：Colorectal cancer  Nigericin  Cancer invasion  Metastasis  Epithelial-mesenchymal transition  CD133  E-cadherin  Vimentin 
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