This work was supported by JSPS KAKENHI(S)JP17H06175,Challenging Research(P)JP18H05376,and AMED-CREST JP20gm1110009 to Yoshimura A;JSPS KAKENHI 17K15667,19H04817,and 19K16618,AMED-PRIME 20gm6210012 to Ito M and by the Tomizawa Jun-ichi&Keiko Fund of Molecular Biology Society of Japan for Young Scientists,a Research Grant for Young Investigators by The Mitsubishi Foundation;the Mochida Memorial Foundation for Medical and Pharmaceutical Research;the Takeda Science Foundation;the Uehara Memorial Foundation;the Naito Memorial Foundation;the Kanae Foundation;the SENSHIN Medical Research Foundation;the Astellas Foundation for Research on Metabolic Disorders,an Inoue Research Award,a Life Science Research Award,and Keio Gijuku Academic Developmental Funds.
After ischemic stroke, proinflammatory molecules known as danger-associated molecular patterns (DAMPs) originating from damaged brain cells recruit and activate immune cells (neutrophils, macrophages, lymphocytes) fur...