PROUROKINASE

作品数：8被引量：4H指数：1
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相关领域：生物学医药卫生更多>>
相关机构：北京大学更多>>
相关期刊：《China Medical Abstracts(Internal Medicine)》《Journal of Chinese Pharmaceutical Sciences》《High Technology Letters》《Chinese Medical Sciences Journal》更多>>
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Rationale and design of ProUrokinase in Mild IsChemic strokE(PUMICE):a multicentre,prospective,randomised,open-label,blinded-endpoint controlled trial
《Stroke & Vascular Neurology》2024年第6期715-722,共8页Yunyun Xiong Manjun Hao Yuesong Pan Chunmiao Duan Xueyan Feng Hao Li Na Wu Liyuan Wang Xia Meng Xingquan Zhao Yongjun Wang the PUMICE investigators 
Background and purpose Recombinant human prourokinase(rhPro-UK)is a new generation of specific plasminogen activator,that is non-inferior to alteplase in acute ischemic stroke.We aimed to investigate the efficacy and ...
关键词：acute PROSPECTIVE centre 
Enhancing cardiac function and hematological parameters in STEMI patients:evaluating the efficacy and safety of ticagrelor combined with prourokinase and reteplase thrombolysis
《Journal of Chinese Pharmaceutical Sciences》2024年第12期1129-1136,共8页Dongjuan Wang Jihong Chen 
To compare the effects of ticagrelor combined with prourokinase and reteplase thrombolysis on cardiac function and blood-related indexes in patients with ST-segment elevation myocardial infarction(STEMI),280 patients ...
关键词：ST segment elevation myocardial infarction THROMBOLYSIS Cardiac function Ticagrelor PROUROKINASE RETEPLASE 
Analysis of the efficacy and safety of prourokinase administration in coronary artery of patients with acute myocardial infarction before PCI
《China Medical Abstracts(Internal Medicine)》2021年第2期92-93,共2页DU Zhengren 
Objective To evaluate the efficacy and safety of prourokinase administration in coronary artery of patients with acute myocardial infarction before PCI.Methods Pubmed,Wanfang Data,CBM,CNKI and VIP databases were searc...
关键词：ARTERY BEFORE PCI 
Design, construction and characterization of prourokinase mutant engineered by introduction of special Lys-Gly-Asp-Trp-motif
《Advances in Biological Chemistry》2013年第2期164-169,共6页Jian Jing 
A recombinant prourokinase chimera was constructed by introduction of Lys-Gly-Asp-Trp-motif between Gly118 and Ile119 among the kringle domain. The structure of designed protein was predicted and simulated. The recomb...
关键词：PROUROKINASE Lys-Gly-Asp-Trp-motif Baculovirus-Insect Cell Expression System Fibrinolytic Activity Anti-Thrombosis Activity 
Simulation,construction and characterization of a multi-functional thrombolytic agent with anti-thrombosis activity
《Frontiers in Biology》2008年第3期265-268,共4页Weiran YU Jian JING 
This work was supported by the National Natural Science Foundation of China(Grant No.30540071).
Prourokinase(scu-PA),a thrombolytic agent,was inserted between Gly118 and Ile119 with foreign anti-thrombosis functional motif(Lys-Gly-Asp-Trp-motif)to construct a multi-functional chimeric molecule.The molecular mode...
关键词：anti-thrombosis thrombolytic agent insect cell BACULOVIRUS prourokinase(scu-PA) foreign functional motif 
Increased production of recombinant prourokinase with porous microcarrier cell culture by periodic pressure oscillation in a stirred tank reactor被引量：3
《High Technology Letters》2006年第3期311-317,共7页胡显文 Gao Lihua Li Zuohu Xiao Chengzu Xu Zhaoping 
An rCHO cell line expressing recombinant human prourokinase （pro-UK） at the level of 5μg/ 10^6cells/d was cultivated on Cytopore cellulose porous microcarriers in a 7.5L Biostat CT stirred tank reactor. A periodic ...
关键词：cell culture porous microcarrier PROUROKINASE periodic pressure oscillation 
A prourokinase-RGDS chimera——Construction, expression and characterization
《Science China(Life Sciences)》1999年第3期259-266,共8页钱斌 孙迎庆 郭雁 党昕 茹炳根 
A tetrapeptide, RGDS, was inserted into proUK kringle domain G118-L119 by the construction of a mutant proUK-RGDS gene. The gene was expressed in the baculovirus expression system. Immunoaffinity chromatography was us...
关键词：RGDS ProUK BIFUNCTIONAL protein THROMBOLYSIS anti-aggregation. 
HIGH　DENSITY　CULTIVATION　OF　A　RECOMBINANT　CD－1　CELL　LINE　PRODUCING　PROUROKINASE　USING　A　BIOSILON　MICROCARRIER　CULTURE　SYSTEM被引量：1
《Chinese Medical Sciences Journal》1994年第4期203-208,共6页肖成祖 黄子才 张正光 叶建新 高丽华 郭智霞 程度胜 周鹤山 孔惟惟 
CD-1, a genetically-engineered CHO cell line, was cultivated with a Biosilon microcarrier culture system.We successfully cultivated CD-1 cells to a very high density (over1×107cells/ml). Prourokinase was stably secre...
关键词：Biosilon microcarrier CD-1 cells line PROUROKINASE high density cultivation 
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