ERBB2

作品数：182被引量：334H指数：9
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相关机构：中国科学技术大学第二军医大学军事医学科学院大连医科大学更多>>
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Genistein suppresses gallbladder cancer tumorigenesis and progression via downregulating ERBB2 mediated PTK6/AKT/MCM pathway
《Science Bulletin》2022年第11期1112-1114,共3页Zhijun Zhou Laura E.Fischer Barish H.Edil Min Li 
Gallbladder cancer(GBC)is the most prevalent cancer type in the biliary tract.Unfortunately,around 80%of patients with GBC are diagnosed at advanced stages with limited options to stop the progression and disseminatio...
关键词：胆囊癌 大豆异黄酮 AKT GENISTEIN 
Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex被引量：9
《Science Bulletin》2022年第8期813-824,M0003,共13页Yajun Geng Shili Chen Yang Yang Huijie Miao Xuechuan Li Guoqiang Li Jian Ma TongZhang Tai Ren Yongsheng Li Lin Li Liguo Liu Jiahua Yang Ziyi Wang Lu Zou Ke Liu Yang Li Siyuan Yan Xuya Cui Xuheng Sun Bo Yang Lingxiao Zhang Xusheng Han Chuanlei Wang BoChen Xueliang Yue Wei Liang Jianjun Ren Jianguang Jia Jianfeng Gu Zhizhen Li Tiansuo Zhao Peng Wang Dong Wei Shimei Qiu Dongxi Xiang Xinsen Xu Wei Chen Min He Linhua Yang Hui Wang Tao Chen Rong Hua Xu’an Wang Xiangsong Wu Wei Gong Guangyi Wang Maolan Li Wei Zhang Rong Shao Wenguang Wu Yingbin Liu 
supported by the National Natural Science Foundation of China(2019XH004,81874181,82073206,21705108,and 81773043);the Emerging Frontier Program of Hospital Development Centre(SHDC12018107);the Key Program of Shanghai Science and Technology Commission(YDZX20193100004049);the State Key Laboratory of Oncogenes and Related Genes(KF2120);the National Key Research and Development Program of China(2021YFE0203300);the Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(20SG14);he Program of Shanghai Academic Research Leader(19XD1422700)。
Soy isoflavones are natural tyrosine kinase inhibitors closely associated with decreased morbidity and mortality of various tumors.The activation of tyrosine kinases such as ERBB2 is the mechanism by which cholecystit...
关键词：Gallbladder cancer Dietary exposure GENISTEIN ERBB2 pathway activation MCM protein complex 
Specific targeted killing of ErbB2 positive breast cancer by retrovirus-mediated Immunocaspase-3 secreting T cells被引量：5
《Chinese Science Bulletin》2004年第13期1380-1385,共6页ZHANGLihong JIALintao ZHAOJing XUYanming WENWeihong BAOWei CAOYunxin SUChenazhi WANGChengji YANGAn-gang 
In this study, lmmunocaspase-3 gene was transfected into Jurkat T lymphocytes and the targeted proapoptotic protein Immunocaspase-3 was stably secreted.Its entry to ErbB2 positive SKBr3 breast carcinoma cell line was ...
关键词：ERBB2 乳癌 逆转录酶病毒 免疫酶 T细胞 CASPASE-3 细胞凋亡 基因治疗 
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