HUMANIZED

作品数：131被引量：178H指数：8
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Application of germ-free NOD-scid IL2rg^(null)mice as a humanized model for tumor microbiome precision medicine
《Science China(Life Sciences)》2021年第4期644-647,共4页Chengwei Wu Haitao Shang Xianhong Jiang Xinning Wang Hong Wei 
supported by grants from the National Key Research and Development Program of China(2017YFD0500503,2017YFD0501000);the National Natural Science Foundation of China(81770434,81370906);the National Program on Key Basic Research Project of China(973 Program)(2007CB513007,2013CB531406)。
In 2013,tumor immunotherapy topped the list of the top ten scientific breakthroughs(Couzin-Frankel,2013),and it was widely used in the treatment of lung cancer,kidney cancer,and melanoma(Routy et al.,2018).However,the...
关键词：al. LUNG cancer 
A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein被引量：15
《Cell Research》2015年第11期1237-1249,共13页Yan Li YuhuaWan Peipei Liu Jincun Zhao Guangwen Lu Jianxun Qi Qihui Wang Xuancheng LU Ying Wu Weniun Liu Buchang Zhang Kwok-Yung Yuen Stanley Perlman George F Gao Jinghua Yan 
the National Basic Research Pro- gram of China （973 Program; 2015CB910503）, the National Sci- ence and Technology Major Project of China （2013ZX10004608- 002 and 2014ZX10004001-006）, the National Natural Science Foundation of China （NSFC; 31400154 and 81461168030）, the National Institutes of Health, USA （AI60699） and Hong Kong Research Grants Council （NHKU728/14）. We acknowledge Dr Kwok-Hung Chan and Dr Jasper FW Chan for their technical support and the staff at the Shanghai Synchrotron Radiation Facility （SSRF-beam line 17U）. We would be grateful to Yuanyuan Chen （Institute of Biophysics, CAS） for technical help with Biacore experiments. GFG is a leading principal investigator of the NSFC Innovative Research Group （8132106）.
The newly-emerging Middle East respiratory syndrome coronavirus （MERS-CoV） can cause severe and fatal acute respiratory disease in humans. Despite global efforts, the potential for an associated pandemic in the futu...
关键词：MERS-CoV neutralizing monoclonal antibody HUMANIZATION crystal structure 
Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes被引量：6
《Science China(Life Sciences)》2011年第3期227-234,共8页SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei ZHU HaiYing HE ZhiYing WANG Xin HU YiPing 
supported by the National High Technology Research and Development Program of China(Grant No. 2006AA02Z474);the National Natural Science Foundation of China(Grant No. 30801115);the China Postdoctoral Science Foundation(Grant No. 20070410743);the National Basic Research Program of China(Grant No. 2010CB945600)
Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver...
关键词：human hepatocyte humanized liver cell transplantation Fah gene knockout mice Nod/Scid mice 
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