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Molecular docking analysis to validate the efficacy of traditional Siddha polyherbal Formulation Aavarai Bhavanai Chooranam(ABC)against enzyme alpha-glucosidase for Type II Diabetes Mellitus: 《TMR Integrative Medicine》2023年第1期1-11,共11页Venkatachalam Lakshmanakumar Gurumurthy Arthi Jayaraj Rathinam Venkatesan Harishanbuselvan Dhanasekaran Sivaraman; Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable diseases.With more than 62 million people in India already living with d...; 关键词：Aavarai Bhavanai Chooranam molecular docking POLYHERBAL DIABETES traditional siddha

In vitro bioaccessibility of phenolic compounds and alpha-glucosidase inhibition activity in yoghurts enriched with mango peel powder被引量：1: 《Food Bioscience》2022年第6期456-464,共9页Hafza Fasiha Zahid Akhtar Ali Chaminda Senaka Ranadheera Zhongxiang Fang Frank R.Dunshea Said Ajlouni; the financial assistance provided to H.F.Z.by the government of Pakistan.; This study investigated the potential health benefits and functional properties of mango peel powder(MPP)as a source of antioxidants and alpha-glucosidase inhibitors in yoghurts with probiotic bacteria.The study invol...; 关键词：Mango peel powder fortified Probiotic yoghurts BIOACCESSIBILITY α-Glucosidase inhibition activity Antioxidant capacity

Is Alpha-Glucosidase Inhibition a Mechanism of the Antidiabetic Action of Garlic (<i>Allium sativum</i>)?被引量：1: 《Journal of Biosciences and Medicines》2019年第10期42-49,共8页Patience Obih John-Clifford Obih Okai Arome; Objective: There has been a global surge in the number of diabetic cases. Many of the agents used as antidiabetic are either expensive or have side effects. Researchers are now turning their attention to phytotherapy ...; 关键词：Diabetes ALPHA-GLUCOSIDASE Medicinal Plants GARLIC (Allium sativum) MECHANISM of Action

Identification of Seven Novel Mutations in the Acid Alpha-glucosidase Gene in Five Chinese Patients with Late-onset Pompe Disease被引量：2: 《Chinese Medical Journal》2018年第4期448-453,共6页Hua-Xu Liu Chuan-Qiang Pu Qiang Shi Yu-Tong Zhang Rui Ban; This work was supported by grants of National Natural Science Foundation of China （No. 81501083 and 81671236）.; Background： Pompe disease is a rare lysosomal glycogen storage disorder linked to the acid alpha-glucosidase gene （GAA）. A wide clinical and genetic variability exists between patients from different ethnic populat...; 关键词：ALPHA-GLUCOSIDASE DNA Mutational Analysis Genetic Heterogeneity Glycogen Storage Disease Type Ⅱ

Evaluation of antiparasitic,anticancer,antimicrobial and hypoglycemic properties of organic extracts from Panamanian mangrove plants: 《Asian Pacific Journal of Tropical Medicine》2018年第1期32-39,共8页Dioxelis Lopez Lilia Cherigo Alejandro de Sedas Carmenza Spadafora Sergio Martinez-Luis; partially supported by the National Secretariat for Science and Technology of Panama(SENACYT)[grant number FID14-063];supported by funds from the National Secretariat of Science,Technology and Innovation(SENACYT)doctoral[grant number 270-2011-154];supported by funds from the National Research System of SENACYT[SNI1472016 and SNI1452016,respectively]; Objective: To investigate 33 organic extracts of mangrove plants for: antiparasitic, anticancer, and antibacterial activities, as well as their ability to inhibit the activity of the α-glucosidase enzyme. Methods: Le...; 关键词：Mangrove plants Anticancer activity Antibacterial activity Antiparasitic activity Alpha-glucosidase inhibition

Computational Study on the Comparative Differences in the Activity of Inhibitors of Human versus Rat Alpha-Glucosidase: 《Open Journal of Medicinal Chemistry》2017年第2期19-28,共10页Shinya Nakamura Kazuko Shimada Genzoh Tanabe Osamu Muraoka Isao Nakanishi; Differences between the inhibitory activities of specific compounds on analogous enzymes isolated from different animal species are one of the critical issues to evaluate when exploring structure-activity relationship...; 关键词：HOMOLOGY Modeling MM/PBSA ALPHA-GLUCOSIDASE Salacinol ACARBOSE Species DIFFERENCE

Antioxidant,anti-alpha-glucosidase and pancreatic beta-cell protective effects of methanolic extract of Ensete superbum Cheesm seeds: 《Asian Pacific Journal of Tropical Biomedicine》2017年第2期121-125,共5页Solomon Habtemariam George Kabakasseril Varghese; Supported by a local grant from the University of Greenwich(GRE Mini-Proof-of-Concept No.HEIF-Po C-SCI-02/13); Objective: To investigate the antioxidant, anti-a-glucosidase and pancreatic b-cell protective potential of Ensete superbum(E. superbum) seeds.Methods: A variety of in vitro assays including radical scavenging, reduci...; 关键词：Ensete superbum MUSACEAE SEEDS ANTIOXIDANT Pancreatic beta-cell protection Alpha-glucosidase inhibition

In vitro inhibition activity of polyphenol-rich extracts from Syzygium aromaticum(L.)Merr.& Perry(Clove)buds against carbohydrate hydrolyzing enzymes linked to type 2 diabetes and Fe^(2+)-induced lipid peroxidation in rat pancreas被引量：11: 《Asian Pacific Journal of Tropical Biomedicine》2012年第10期774-781,共8页Stephen Adeniyi Adefegha Ganiyu Oboh; To investigate and compare the inhibitory properties of free and bound phenolic extracts of clove bud against carbohydrate hydrolyzing enzymes (alpha-amylase & alpha-glucosidase) and Fe2+-induced lipid peroxidation in...; 关键词：ALPHA-AMYLASE ALPHA-GLUCOSIDASE Fe^(2+)-induced lipid peroxidation Pancrea Phenol Antioxidant

Homology Modeling of Human Alpha-Glucosidase Catalytic Domains and SAR Study of Salacinol Derivatives: 《Open Journal of Medicinal Chemistry》2012年第3期50-60,共11页Shinya Nakamura Kazunori Takahira Genzoh Tanabe Osamu Muraoka Isao Nakanishi; Maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) belong to human intestinal alpha-glucosidase and their N-terminal side catalytic domains are called NtMGAM and NtSI, and their C-terminal side catalytic domains ...; 关键词：HOMOLOGY Modeling DOCKING Study MM/PBSA ALPHA-GLUCOSIDASE Salacinol Kotalanol

Effect of experimental varicocele on structure and function of epididymis in adolescent rats被引量：25: 《Asian Journal of Andrology》2003年第2期108-112,共5页Qiu-YangZHANG Shu-DongQIU Xiao-NianMA He-MingYU Yan-WanWU; Aim: To study the effect of experimental left varicocele (ELV) on epididymal structure and function in adolescent Sprague-Dawley rats. Methods: ELV was induced by partial ligation of the left renal vein. Sha...; 关键词：experimental varicocele EPIDIDYMIS ULTRASTRUCTURE L-CARNITINE ALPHA-GLUCOSIDASE adolescent rat

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